TRIM64C Gene - Tripartite Motif Containing 64C
A comprehensive biomedical resource on TRIM64C: genomic context, expression, and disease associations.
Gene Information Card
| Symbol | TRIM64C |
|---|---|
| Full Name | Tripartite Motif Containing 64C |
| Gene Type | protein coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000275302 |
| UniProt ID | A6NKF1 |
| OMIM ID | Not available |
| HGNC ID | 37233 |
| Aliases | TRIM64, TRIM64B, TRIM64C (gene family) |
Description
TRIM64C is a protein-coding gene belonging to the tripartite motif (TRIM) family, characterized by RING finger, B-box, and coiled-coil domains. It is located on chromosome 11p15.4 and is part of a gene cluster with TRIM64 and TRIM64B. The protein is predicted to function in ubiquitination and innate immune signaling, though its specific roles are not fully characterized. Expression data indicate low to moderate levels in various tissues, with potential involvement in cancer and immune responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Not established | No direct disease association reported in curated databases. | No evidence from ClinVar, OMIM, or COSMIC. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.8 | Low |
| Thyroid | 0.5 | Low |
| Adrenal Gland | 0.4 | Low |
| Bone Marrow | 0.3 | Low |
| Lung | 0.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 0.1 | Low expression |
| HeLa | 0.2 | Low expression |
| A549 | 0.1 | Low expression |
| GM12878 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | Not applicable | Not available | No functional effect reported |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function mutations have been characterized for TRIM64C.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative effects are documented.
View complete mutation data：
Gene Ontology (GO)
| • protein ubiquitination | • zinc ion binding |
| • innate immune response | • ubiquitin-protein transferase activity |
Pathways
• Ubiquitin-Proteasome Pathway
• Innate Immune Signaling (predicted)
Protein Summary
The TRIM64C protein is a member of the TRIM family, featuring a RING-type zinc finger domain, B-box domains, and a coiled-coil region. It is predicted to act as an E3 ubiquitin ligase, potentially targeting substrates for proteasomal degradation. Its expression is low across tissues, and its physiological function remains largely unexplored, though it may play a role in antiviral defense or cell proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM64C Knockout HEK293 Cell Line | EDJ-KQ15129 | Human | 646754 | Details Get a Quote |
| TRIM64C Knockout HeLa Cell Line | EDJ-KQ60613 | Human | 646754 | Details Get a Quote |
| TRIM64C Knockout A-549 Cell Line | EDJ-KQ69082 | Human | 646754 | Details Get a Quote |
| TRIM64C Knockout HCT 116 Cell Line | EDJ-KQ77436 | Human | 646754 | Details Get a Quote |
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