TRIM64B
Tripartite Motif Containing 64B
Gene Information Card
| Symbol | TRIM64B |
|---|---|
| Full Name | tripartite motif containing 64B |
| Gene Type | protein-coding |
| Chromosomal Location | 11q24.3 |
| NCBI Gene ID | 100129405 ncbi.nlm.nih.gov/gene/100129405 |
| Ensembl ID | ENSG00000204103 |
| UniProt ID | A6NKF1 |
| OMIM ID | Not available |
| HGNC ID | HGNC:37249 |
| Aliases | TRIM64, TRIM64A |
Description
TRIM64B is a protein-coding gene belonging to the tripartite motif (TRIM) family, characterized by a RING finger domain, B-box zinc finger, and coiled-coil region. It is located on chromosome 11q24.3 and is involved in protein ubiquitination and innate immune signaling. Limited functional characterization exists; expression is detected in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Lymph node | 3.1 | Low |
| Spleen | 2.8 | Low |
| Bone marrow | 2.5 | Low |
| Other tissues | <2.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 1.5 | Low expression |
| K562 | 0.8 | Very low |
| HeLa | 0.5 | Very low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • protein ubiquitination | • zinc ion binding |
| • innate immune response |
Pathways
• Ubiquitin-proteasome pathway (inferred)
Protein Summary
The TRIM64B protein (UniProt A6NKF1) contains a RING-type zinc finger domain, B-box zinc finger, and coiled-coil region, typical of TRIM family E3 ubiquitin ligases. It may function in ubiquitination and antiviral signaling, but detailed biochemical characterization is lacking.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM64B Knockout HEK293 Cell Line | EDJ-KQ15927 | Human | 642446 | Details Get a Quote |
| TRIM64B Knockout HeLa Cell Line | EDJ-KQ60525 | Human | 642446 | Details Get a Quote |
| TRIM64B Knockout A-549 Cell Line | EDJ-KQ68995 | Human | 642446 | Details Get a Quote |
| TRIM64B Knockout HCT 116 Cell Line | EDJ-KQ77353 | Human | 642446 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
