TRIM61
Tripartite Motif Containing 61
Gene Information Card
| Symbol | TRIM61 |
|---|---|
| Full Name | Tripartite Motif Containing 61 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q32.3 |
| NCBI Gene ID | 391714 ncbi.nlm.nih.gov/gene/391714 |
| Ensembl ID | ENSG00000204388 |
| UniProt ID | Q8N6T7 |
| OMIM ID | Not available |
| HGNC ID | 26031 |
| Aliases | RNF35, FLJ40342 |
Description
TRIM61 (Tripartite Motif Containing 61) is a protein-coding gene belonging to the tripartite motif (TRIM) family. The encoded protein contains a RING finger domain, B-box zinc finger, and coiled-coil region, suggesting roles in ubiquitination and innate immunity. TRIM61 is primarily expressed in testis and certain immune cells, with limited functional characterization.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Lymph node | 2.1 | Not detected |
| Spleen | 1.8 | Not detected |
| Other tissues | <1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.5 | Low expression |
| K562 | 0.3 | Low expression |
| HeLa | 0.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | Not available | Not available | Not available |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • protein ubiquitination | • zinc ion binding |
| • innate immune response |
Pathways
• Ubiquitin mediated proteolysis (KEGG)
Protein Summary
TRIM61 is a 493-amino acid protein with a molecular weight of approximately 56 kDa. It contains a RING-type zinc finger domain (residues 15-55), two B-box-type zinc fingers (residues 89-132 and 144-187), and a coiled-coil region (residues 200-250). The protein is predicted to function as an E3 ubiquitin ligase, potentially involved in antiviral defense and protein degradation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM61 Knockout HEK293 Cell Line | EDJ-KQ15925 | Human | 391712 | Details Get a Quote |
| TRIM61 Knockout HeLa Cell Line | EDJ-KQ60221 | Human | 391712 | Details Get a Quote |
| TRIM61 Knockout A-549 Cell Line | EDJ-KQ68683 | Human | 391712 | Details Get a Quote |
| TRIM61 Knockout HCT 116 Cell Line | EDJ-KQ77050 | Human | 391712 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
