TRIM60: Tripartite Motif Containing 60
A TRIM family protein with roles in innate immunity and potential implications in cancer
Gene Information Card
| Symbol | TRIM60 |
|---|---|
| Full Name | tripartite motif containing 60 |
| Gene Type | protein coding |
| Chromosomal Location | 4q32.3 |
| NCBI Gene ID | 200424 ncbi.nlm.nih.gov/gene/200424 |
| Ensembl ID | ENSG00000164168 |
| UniProt ID | Q6ZUT1 |
| OMIM ID | 616311 |
| HGNC ID | 26787 |
| Aliases | RNF129, TRIM60A, TRIM60B |
Description
TRIM60 (tripartite motif containing 60) is a protein-coding gene belonging to the tripartite motif (TRIM) family, characterized by a RING finger domain, B-box zinc finger, and coiled-coil region. TRIM60 is involved in innate immune signaling, particularly as a negative regulator of antiviral responses. It is expressed in multiple tissues and has been implicated in certain cancers through altered expression and potential oncogenic roles.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered TRIM60 expression may modulate NF-κB and interferon pathways, affecting tumor progression | Limited; expression changes observed in cancer cell lines and tumor samples (COSMIC) |
| Viral infections | TRIM60 negatively regulates RIG-I-like receptor signaling, reducing antiviral cytokine production | Inferred from functional studies (UniProt) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Spleen | 8.3 | Low |
| Lung | 6.1 | Low |
| Kidney | 5.4 | Low |
| Liver | 4.2 | Low |
| Brain | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 3.8 | Low expression |
| HeLa | 2.5 | Low expression |
| K562 | 1.2 | Very low expression |
| MCF7 | 4.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Ala34Val) | Missense | 0.02% (gnomAD) | Unknown functional impact |
| c.457G>A (p.Glu153Lys) | Missense | 0.01% (gnomAD) | Unknown functional impact |
| c.832_833insA (p.Thr278Asnfs*5) | Frameshift | Rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Thr278Asnfs*5) are predicted to cause premature truncation and loss of TRIM60 protein function.
Gain of Function (GOF)
No gain-of-function mutations have been reported for TRIM60.
Dominant Negative (DN)
No dominant-negative mutations have been described for TRIM60.
View complete mutation data：
Gene Ontology (GO)
Pathways
• RIG-I-like receptor signaling pathway (negative regulation)
• Innate immune system
Protein Summary
TRIM60 is a 493-amino acid protein with a molecular weight of approximately 56 kDa. It contains a RING-type zinc finger domain (residues 15-55) that confers E3 ubiquitin ligase activity, two B-box zinc fingers (residues 88-131 and 140-183), and a coiled-coil region (residues 197-240). TRIM60 localizes to the cytoplasm and negatively regulates antiviral signaling by targeting RIG-I for ubiquitination and degradation. Its expression is highest in testis and spleen, with lower levels in other tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM60 Knockout HEK293 Cell Line | EDJ-KQ15924 | Human | 166655 | Details Get a Quote |
| TRIM60 Knockout HeLa Cell Line | EDJ-KQ58896 | Human | 166655 | Details Get a Quote |
| TRIM60 Knockout A-549 Cell Line | EDJ-KQ67386 | Human | 166655 | Details Get a Quote |
| TRIM60 Knockout HCT 116 Cell Line | EDJ-KQ75779 | Human | 166655 | Details Get a Quote |
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