TRIM6: Tripartite Motif Containing 6
A member of the TRIM protein family involved in innate immunity and ubiquitination
Gene Information Card
| Symbol | TRIM6 |
|---|---|
| Full Name | Tripartite Motif Containing 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 117854 ncbi.nlm.nih.gov/gene/117854 |
| Ensembl ID | ENSG00000133872 |
| UniProt ID | Q9C030 |
| OMIM ID | 607564 |
| HGNC ID | 16277 |
| Aliases | RNF89, TRIM6-7 |
Description
TRIM6 (Tripartite Motif Containing 6) encodes a member of the tripartite motif (TRIM) family. The protein contains a RING finger domain, B-box, and coiled-coil region, and functions as an E3 ubiquitin ligase. TRIM6 is involved in innate immune signaling, particularly in the regulation of interferon responses and antiviral defense.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Influenza A infection | TRIM6 ubiquitinates and activates IKKε, promoting antiviral interferon production | PMID: 25282101 |
| Viral encephalitis | TRIM6 deficiency impairs interferon signaling, increasing susceptibility to viral infections | PMID: 25282101 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.3 | Medium |
| Spleen | 10.8 | Medium |
| Bone marrow | 9.5 | Medium |
| Lung | 6.2 | Low |
| Testis | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | High expression |
| HeLa | 8.7 | Moderate expression |
| K562 | 6.4 | Low expression |
| HepG2 | 4.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Unknown functional impact |
| c.1012G>A (p.Glu338Lys) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations in TRIM6 impair IKKε ubiquitination and reduce interferon induction, leading to increased susceptibility to viral infections.
Gain of Function (GOF)
No gain-of-function mutations have been reported for TRIM6.
Dominant Negative (DN)
No dominant-negative mutations have been described for TRIM6.
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin-protein transferase activity (GO:0004842) | • protein binding (GO:0005515) |
| • innate immune response (GO:0045087) | • ubiquitin protein ligase activity (GO:0061630) |
| • cytoplasm (GO:0005737) |
Pathways
• RIG-I-like receptor signaling pathway (KEGG: hsa04622)
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
Protein Summary
TRIM6 is a 513-amino acid protein with a molecular weight of approximately 58 kDa. It contains a RING-type zinc finger domain (residues 15-54), two B-box-type zinc fingers (residues 91-132 and 160-201), and a coiled-coil region (residues 210-250). The RING domain confers E3 ubiquitin ligase activity, enabling TRIM6 to ubiquitinate target proteins such as IKKε, thereby modulating antiviral signaling pathways.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM65 Knockout HEK293 Cell Line | EDJ-KQ970 | Human | 201292 | Details Get a Quote |
| TRIM63 Knockout HEK293 Cell Line | EDJ-KQ2173 | Human | 84676 | Details Get a Quote |
| TRIM66 Knockout HEK293 Cell Line | EDJ-KQ6134 | Human | 9866 | Details Get a Quote |
| TRIM6 Knockout HEK293 Cell Line | EDJ-KQ7614 | Human | 117854 | Details Get a Quote |
| TRIM69 Knockout HEK293 Cell Line | EDJ-KQ9795 | Human | 140691 | Details Get a Quote |
| TRIM64C Knockout HEK293 Cell Line | EDJ-KQ15129 | Human | 646754 | Details Get a Quote |
| TRIM60 Knockout HEK293 Cell Line | EDJ-KQ15924 | Human | 166655 | Details Get a Quote |
| TRIM61 Knockout HEK293 Cell Line | EDJ-KQ15925 | Human | 391712 | Details Get a Quote |
| TRIM62 Knockout HEK293 Cell Line | EDJ-KQ15926 | Human | 55223 | Details Get a Quote |
| TRIM64B Knockout HEK293 Cell Line | EDJ-KQ15927 | Human | 642446 | Details Get a Quote |
| TRIM67 Knockout HEK293 Cell Line | EDJ-KQ15928 | Human | 440730 | Details Get a Quote |
| TRIM68 Knockout HEK293 Cell Line | EDJ-KQ15929 | Human | 55128 | Details Get a Quote |
| TRIM65 Knockout A-549 Cell Line | EDJ-KQ19978 | Human | 201292 | Details Get a Quote |
| TRIM65 Knockout HCT 116 Cell Line | EDJ-KQ19979 | Human | 201292 | Details Get a Quote |
| TRIM65 Knockout HeLa Cell Line | EDJ-KQ19980 | Human | 201292 | Details Get a Quote |
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