TRIM58: A Key Regulator in Erythropoiesis and Tumor Suppression
Comprehensive genomic and functional analysis of the tripartite motif-containing protein 58 gene
Gene Information Card
| Symbol | TRIM58 |
|---|---|
| Full Name | tripartite motif containing 58 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q44 |
| NCBI Gene ID | 25873 ncbi.nlm.nih.gov/gene/25873 |
| Ensembl ID | ENSG00000162614 |
| UniProt ID | Q8NG27 |
| OMIM ID | 616977 |
| HGNC ID | 25231 |
| Aliases | BIA2, RNF188 |
Description
TRIM58 (tripartite motif containing 58) is a protein-coding gene located on chromosome 1q44. It belongs to the TRIM/RBCC family, characterized by a RING finger, B-box, and coiled-coil domains. TRIM58 acts as an E3 ubiquitin ligase and is involved in erythropoiesis, specifically in the terminal differentiation of erythroid cells. It also functions as a tumor suppressor in various cancers, including hepatocellular carcinoma and lung cancer, by promoting ubiquitination and degradation of key oncoproteins.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | TRIM58 downregulation leads to increased c-Myc stability and proliferation | PMID: 28431213 |
| Lung cancer | Loss of TRIM58 expression correlates with poor prognosis and metastasis | PMID: 29367642 |
| Colorectal cancer | TRIM58 promoter hypermethylation silences gene expression | PMID: 26045208 |
| Erythroid disorders | TRIM58 mutations impair terminal erythroid differentiation | PMID: 25505247 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | High |
| Spleen | 8.3 | Medium |
| Liver | 2.1 | Low |
| Lung | 1.5 | Low |
| Kidney | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 (erythroleukemia) | 45.2 | High expression; model for erythropoiesis |
| HepG2 (hepatocellular carcinoma) | 3.1 | Low expression; silenced in cancer |
| A549 (lung adenocarcinoma) | 1.8 | Low expression; tumor suppressor loss |
| HEK293 (embryonic kidney) | 0.5 | Minimal expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | 0.01% | Loss of start codon; likely loss of function |
| c.100C>T (p.Arg34Trp) | missense | 0.02% | Alters RING finger domain; impaired ubiquitin ligase activity |
| c.250_251del (p.Leu84fs) | frameshift | 0.005% | Premature truncation; loss of function |
Mutation functional classification
Loss of Function (LOF)
Most reported TRIM58 mutations (missense, frameshift, nonsense) result in loss of E3 ubiquitin ligase activity, leading to accumulation of oncogenic substrates such as c-Myc.
Gain of Function (GOF)
No gain-of-function mutations have been documented for TRIM58.
Dominant Negative (DN)
No dominant-negative mutations have been reported for TRIM58.
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin-protein transferase activity (GO:0004842) | • zinc ion binding (GO:0008270) |
| • protein ubiquitination (GO:0016567) | • erythrocyte differentiation (GO:0030218) |
| • identical protein binding (GO:0042802) | • canonical glycolysis (GO:0061621) |
Pathways
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
• p53 signaling pathway (KEGG: hsa04115) - indirect via c-Myc regulation
• Erythropoietin signaling pathway (Reactome: R-HSA-9006335)
Protein Summary
TRIM58 is a 513-amino acid protein (UniProt Q8NG27) belonging to the TRIM/RBCC family. It contains a RING finger domain (residues 15-56) that confers E3 ubiquitin ligase activity, two B-box domains (residues 90-133 and 164-207), and a coiled-coil region (residues 214-260). The protein localizes to the cytoplasm and nucleus. TRIM58 mediates ubiquitination and degradation of c-Myc, thereby suppressing cell proliferation and tumorigenesis. It is highly expressed in erythroid cells and is essential for terminal erythroid differentiation. Loss of TRIM58 expression due to promoter hypermethylation or mutation is associated with multiple cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM58 Knockout HEK293 Cell Line | EDJ-KQ8285 | Human | 25893 | Details Get a Quote |
| TRIM58 Knockout HeLa Cell Line | EDJ-KQ55844 | Human | 25893 | Details Get a Quote |
| TRIM58 Knockout A-549 Cell Line | EDJ-KQ64333 | Human | 25893 | Details Get a Quote |
| TRIM58 Knockout HCT 116 Cell Line | EDJ-KQ72787 | Human | 25893 | Details Get a Quote |
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