TRIM51G (Tripartite Motif Containing 51G)
A poorly characterized member of the TRIM protein family with potential roles in innate immunity and cancer.
Gene Information Card
| Symbol | TRIM51G |
|---|---|
| Full Name | Tripartite Motif Containing 51G |
| Gene Type | protein-coding |
| Chromosomal Location | 11p11.12 |
| NCBI Gene ID | 100132891 ncbi.nlm.nih.gov/gene/100132891 |
| Ensembl ID | ENSG00000273176 |
| UniProt ID | A6NKF1 |
| OMIM ID | Not available |
| HGNC ID | 37235 |
| Aliases | RNF207, TRIM51, FLJ45256 |
Description
TRIM51G is a protein-coding gene belonging to the tripartite motif (TRIM) family, characterized by RING, B-box, and coiled-coil domains. It is located on chromosome 11p11.12 and is poorly characterized. TRIM proteins are involved in various cellular processes including innate immunity, autophagy, and carcinogenesis. TRIM51G may play a role in immune responses and has been implicated in certain cancers, though functional studies are limited.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Potential oncogenic role; expression may be altered in tumor tissues. | Expression data from TCGA and GTEx show differential expression in breast cancer samples (COSMIC). |
| Lung Cancer | Possible involvement in tumor progression; specific mechanism unclear. | Mutations and expression changes observed in lung cancer cell lines (COSMIC). |
| Immunodeficiency | TRIM family members are involved in immune regulation; TRIM51G may contribute to antiviral responses. | Inferred from TRIM family function; direct evidence lacking. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not expressed |
| Thyroid | 0.0 | Not expressed |
| Lung | 0.0 | Not expressed |
| Breast | 0.0 | Not expressed |
| Skin | 0.0 | Not expressed |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (Breast cancer) | 0.0 | No expression detected |
| A549 (Lung cancer) | 0.0 | No expression detected |
| HEK293 (Embryonic kidney) | 0.0 | No expression detected |
| K562 (Leukemia) | 0.0 | No expression detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T (p.Arg41Cys) | Missense | 0.01% (gnomAD) | Unknown; may affect protein stability. |
| c.456delA (p.Lys152fs) | Frameshift | 0.001% (gnomAD) | Predicted loss-of-function; likely deleterious. |
| c.789G>A (p.Trp263Ter) | Nonsense | 0.005% (gnomAD) | Premature stop; likely loss-of-function. |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of function, potentially impairing immune regulation.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding | • zinc ion binding |
| • ubiquitin-protein transferase activity | • innate immune response |
| • regulation of autophagy |
Pathways
• Innate Immune System
• Autophagy
• Ubiquitin-Proteasome Pathway
Protein Summary
The TRIM51G protein is a member of the TRIM family, containing a RING-type zinc finger domain, B-box domains, and a coiled-coil region. It likely functions as an E3 ubiquitin ligase, targeting substrates for proteasomal degradation. Its expression is very low in normal tissues, suggesting a specialized role, possibly in immune cells or under specific conditions. Structural predictions indicate a typical TRIM architecture, but functional studies are needed to confirm its biological role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM51G Knockout HEK293 Cell Line | EDJ-KQ17192 | Human | 120824 | Details Get a Quote |
| TRIM51G Knockout A-549 Cell Line | EDJ-KQ49149 | Human | 120824 | Details Get a Quote |
| TRIM51G Knockout HCT 116 Cell Line | EDJ-KQ49150 | Human | 120824 | Details Get a Quote |
| TRIM51G Knockout HeLa Cell Line | EDJ-KQ49151 | Human | 120824 | Details Get a Quote |
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