TRIM39: Tripartite Motif Containing 39
A RING finger protein involved in cell cycle regulation and immune signaling
Gene Information Card
| Symbol | TRIM39 |
|---|---|
| Full Name | Tripartite Motif Containing 39 |
| Gene Type | Protein coding |
| Chromosomal Location | 6p22.1 |
| NCBI Gene ID | 56658 ncbi.nlm.nih.gov/gene/56658 |
| Ensembl ID | ENSG00000112742 |
| UniProt ID | Q9HCM9 |
| OMIM ID | 607477 |
| HGNC ID | 16267 |
| Aliases | RNF23, TMA7 |
Description
TRIM39 (Tripartite Motif Containing 39) is a member of the tripartite motif (TRIM) family, characterized by a RING finger domain, B-box zinc finger, and coiled-coil region. The gene encodes a protein involved in ubiquitination, cell cycle regulation, and modulation of innate immune responses. TRIM39 interacts with and regulates the stability of cell cycle proteins such as p21 and cyclin D1, and has been implicated in cancer progression and inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | TRIM39 overexpression promotes cell proliferation and inhibits apoptosis via p21 degradation | COSMIC, NCBI |
| Colorectal cancer | TRIM39 upregulation correlates with poor prognosis and enhanced tumor growth | COSMIC, NCBI |
| Systemic lupus erythematosus | TRIM39 polymorphisms associated with increased risk | OMIM, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.3 | Medium |
| Spleen | 7.1 | Medium |
| Liver | 4.2 | Low |
| Colon | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.1 | Hepatocellular carcinoma cell line |
| HCT116 | 9.5 | Colorectal carcinoma cell line |
| K562 | 6.8 | Leukemia cell line |
| HEK293 | 5.2 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | 0.01% | Unknown functional impact |
| c.1015G>A (p.Gly339Arg) | Missense | 0.005% | Reported in COSMIC for colorectal cancer |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; some missense variants may impair ubiquitin ligase activity.
Gain of Function (GOF)
Overexpression in cancers suggests potential gain-of-function in promoting cell proliferation.
Dominant Negative (DN)
No evidence currently available.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
• Cell cycle (Reactome: R-HSA-1640170)
Protein Summary
TRIM39 is a 465-amino acid protein with a molecular weight of approximately 53 kDa. It contains an N-terminal RING finger domain (residues 15-55) that confers E3 ubiquitin ligase activity, followed by a B-box zinc finger (residues 90-130) and a coiled-coil region (residues 160-200). The protein localizes to the cytoplasm and mediates ubiquitination of target proteins such as p21, thereby regulating cell cycle progression. TRIM39 also interacts with the innate immune adaptor MAVS, modulating antiviral signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM39 Knockout HEK293 Cell Line | EDJ-KQ17185 | Human | 56658 | Details Get a Quote |
| TRIM39 Knockout A-549 Cell Line | EDJ-KQ49143 | Human | 56658 | Details Get a Quote |
| TRIM39 Knockout HCT 116 Cell Line | EDJ-KQ49144 | Human | 56658 | Details Get a Quote |
| TRIM39 Knockout HeLa Cell Line | EDJ-KQ49145 | Human | 56658 | Details Get a Quote |
| TRIM39-RPP21 Knockout HEK293 Cell Line | EDJ-KQ52138 | Human | 202658 | Details Get a Quote |
| TRIM39-RPP21 Knockout HeLa Cell Line | EDJ-KQ59036 | Human | 202658 | Details Get a Quote |
| TRIM39-RPP21 Knockout A-549 Cell Line | EDJ-KQ67515 | Human | 202658 | Details Get a Quote |
| TRIM39-RPP21 Knockout HCT 116 Cell Line | EDJ-KQ75913 | Human | 202658 | Details Get a Quote |
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