TRIM36 Gene - Tripartite Motif Containing 36 | Function, Mutations & Disease

TRIM36 (Tripartite Motif Containing 36) encodes a member of the tripartite motif (TRIM) family, characterized by a RING finger domain, B-box zinc finger, and coiled-coil region. The protein functions as an E3 ubiquitin ligase, mediating ubiquitination and proteasomal degradation of target proteins. TRIM36 is involved in cell cycle regulation, microtubule stabilization, and neurodevelopment. It is expressed in multiple tissues, with highest levels in testis and brain. Mutations and altered expression have been associated with cancer and neurological disorders.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Ubiquitin mediated proteolysis (KEGG: hsa04120)

• Cell cycle (Reactome: R-HSA-1640170)

TRIM36 is a 728-amino acid protein with a molecular weight of approximately 82 kDa. It contains an N-terminal RING finger domain (E3 ubiquitin ligase activity), two B-box zinc fingers, a coiled-coil region, and a C-terminal SPRY domain. The protein localizes to the cytoplasm and centrosome, where it regulates microtubule dynamics and cell cycle progression. TRIM36 ubiquitinates target proteins such as cyclins and spindle-associated factors, targeting them for proteasomal degradation. Its expression is enriched in testis and brain, suggesting roles in spermatogenesis and neuronal development.