TRIM33: Tripartite Motif Containing 33
A key regulator of TGF-beta signaling and tumor suppression
Gene Information Card
| Symbol | TRIM33 |
|---|---|
| Full Name | tripartite motif containing 33 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p13.2 |
| NCBI Gene ID | 51592 ncbi.nlm.nih.gov/gene/51592 |
| Ensembl ID | ENSG00000197385 |
| UniProt ID | Q9UPN9 |
| OMIM ID | 605769 |
| HGNC ID | 16290 |
| Aliases | TIF1-gamma, PTC7, RFG7, TIF1GAMMA |
Description
TRIM33 (tripartite motif containing 33), also known as TIF1-gamma, encodes a member of the tripartite motif (TRIM) family. The protein functions as a transcriptional repressor and is a key regulator of TGF-beta signaling by interacting with SMAD proteins. It plays roles in cell differentiation, proliferation, and tumor suppression. Mutations and altered expression of TRIM33 have been implicated in various cancers and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Loss of TRIM33 expression leads to enhanced TGF-beta signaling and tumor progression | PMID: 24651015 |
| Pancreatic cancer | TRIM33 mutations impair SMAD4-mediated transcriptional repression | PMID: 26030138 |
| Acute myeloid leukemia | TRIM33 fusions (e.g., with NUP98) drive leukemogenesis | PMID: 17327258 |
| Colorectal cancer | Reduced TRIM33 expression correlates with poor prognosis and metastasis | PMID: 29187737 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Pancreas | 8.3 | Low |
| Bone marrow | 6.1 | Low |
| Lung | 15.2 | Medium |
| Kidney | 10.8 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 18.4 | Hepatocellular carcinoma cell line |
| PANC-1 | 7.2 | Pancreatic cancer cell line |
| K562 | 5.9 | Chronic myeloid leukemia cell line |
| A549 | 14.1 | Lung adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | 0.5% in hepatocellular carcinoma | Loss of function |
| c.1567_1568insA (p.Thr523Asnfs*2) | Frameshift | 0.3% in pancreatic cancer | Loss of function |
| c.2101G>A (p.Gly701Arg) | Missense | 0.1% in colorectal cancer | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations leading to truncated protein or nonsense-mediated decay, impairing TGF-beta repression.
Gain of Function (GOF)
Not well documented; no recurrent activating mutations reported.
Dominant Negative (DN)
Some missense mutations may interfere with wild-type TRIM33 function, but evidence is limited.
View complete mutation data：
Gene Ontology (GO)
Pathways
• TGF-beta signaling pathway (KEGG: hsa04350)
• SMAD2/SMAD3:SMAD4 transcription factor complex
Protein Summary
TRIM33 is a 1120-amino acid protein containing a RING finger domain, B-box domains, and a coiled-coil region characteristic of the TRIM family. It acts as a transcriptional corepressor by recruiting histone deacetylases and interacting with SMAD proteins to modulate TGF-beta signaling. The protein is predominantly nuclear and is involved in cell cycle control, differentiation, and tumor suppression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM33 Knockout HEK293 Cell Line | EDJ-KQ11152 | Human | 51592 | Details Get a Quote |
| TRIM33 Knockout HCT 116 Cell Line | EDJ-KQ39158 | Human | 51592 | Details Get a Quote |
| TRIM33 Knockout HeLa Cell Line | EDJ-KQ39159 | Human | 51592 | Details Get a Quote |
| TRIM33 Knockout A-549 Cell Line | EDJ-KQ37843 | Human | 51592 | Details Get a Quote |
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