TRIM31: Tripartite Motif Containing 31
A RING-type E3 ubiquitin ligase involved in innate immunity, autophagy, and tumor suppression.
Gene Information Card
| Symbol | TRIM31 |
|---|---|
| Full Name | Tripartite Motif Containing 31 |
| Gene Type | Protein coding |
| Chromosomal Location | 6p21.31 |
| NCBI Gene ID | 11074 ncbi.nlm.nih.gov/gene/11074 |
| Ensembl ID | ENSG00000112210 |
| UniProt ID | Q9BZY9 |
| OMIM ID | 606247 |
| HGNC ID | 16291 |
| Aliases | RNF, HCG1, RNF9 |
Description
TRIM31 (Tripartite Motif Containing 31) is a protein-coding gene that belongs to the TRIM/RBCC family. It encodes a RING-type E3 ubiquitin ligase involved in ubiquitination and proteasomal degradation of target proteins. TRIM31 plays critical roles in innate immune signaling, autophagy regulation, and tumor suppression. It is located in the MHC class I region on chromosome 6p21.31.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | TRIM31 acts as a tumor suppressor by promoting ubiquitination and degradation of oncogenic proteins such as TAK1 and p62. Loss of TRIM31 expression correlates with poor prognosis. | PMID: 32015527 |
| Gastric cancer | TRIM31 suppresses tumor growth and metastasis by inhibiting NF-κB signaling through ubiquitination of NEMO. | PMID: 30948266 |
| Inflammatory bowel disease | TRIM31 negatively regulates NLRP3 inflammasome activation by targeting NLRP3 for ubiquitination and degradation. | PMID: 27574249 |
| Viral infections | TRIM31 restricts viral replication by targeting viral proteins for degradation and modulating interferon signaling. | PMID: 28712727 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.2 | Medium |
| Lung | 6.1 | Low |
| Spleen | 4.8 | Low |
| Testis | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.3 | Hepatocellular carcinoma cell line |
| HEK293 | 9.7 | Embryonic kidney cells |
| A549 | 7.4 | Lung adenocarcinoma cells |
| MCF7 | 5.1 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.511C>T (p.Arg171Trp) | Missense | <0.01% | Unknown functional effect |
| c.832G>A (p.Glu278Lys) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Reduced E3 ligase activity or protein stability; associated with increased oncogenic signaling.
Gain of Function (GOF)
Not well documented; potential enhanced degradation of tumor suppressors.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• NOD-like receptor signaling pathway (KEGG: hsa04621)
• NF-kappa B signaling pathway (KEGG: hsa04064)
• Autophagy - animal (KEGG: hsa04140)
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
Protein Summary
TRIM31 is a 488-amino acid protein containing a RING finger domain, B-box type 1 and type 2, and a coiled-coil region. It functions as an E3 ubiquitin ligase, catalyzing the transfer of ubiquitin to specific substrates, leading to their proteasomal degradation. TRIM31 regulates key signaling pathways including NF-κB, NLRP3 inflammasome, and autophagy. It is widely expressed in immune tissues and acts as a tumor suppressor in several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM31 Knockout HEK293 Cell Line | EDJ-KQ7271 | Human | 11074 | Details Get a Quote |
| TRIM31 Knockout A-549 Cell Line | EDJ-KQ32292 | Human | 11074 | Details Get a Quote |
| TRIM31 Knockout HeLa Cell Line | EDJ-KQ55562 | Human | 11074 | Details Get a Quote |
| TRIM31 Knockout HCT 116 Cell Line | EDJ-KQ72507 | Human | 11074 | Details Get a Quote |
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