TRIM29: Tripartite Motif Containing 29
A gene encoding a protein involved in DNA repair, immune response, and cancer progression.
Gene Information Card
| Symbol | TRIM29 |
|---|---|
| Full Name | Tripartite Motif Containing 29 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q23.3 |
| NCBI Gene ID | 23650 ncbi.nlm.nih.gov/gene/23650 |
| Ensembl ID | ENSG00000137699 |
| UniProt ID | Q14134 |
| OMIM ID | 604768 |
| HGNC ID | 17274 |
| Aliases | ATDC |
Description
TRIM29 (Tripartite Motif Containing 29), also known as ATDC (Ataxia Telangiectasia Group D Complementing), is a protein-coding gene located on chromosome 11q23.3. The encoded protein belongs to the tripartite motif (TRIM) family and is involved in DNA damage response, regulation of p53, and immune signaling. TRIM29 is implicated in various cancers, including lung, breast, and gastric cancers, where it can act as an oncogene or tumor suppressor depending on the context.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung Cancer | Overexpression promotes cell proliferation and invasion | PMID: 25605247 |
| Breast Cancer | Upregulation associated with poor prognosis and metastasis | PMID: 27323851 |
| Gastric Cancer | TRIM29 silencing reduces tumor growth | PMID: 28407145 |
| Pancreatic Cancer | ATDC expression enhances resistance to chemotherapy | PMID: 19668341 |
| Nasopharyngeal Carcinoma | High expression correlates with advanced stage | PMID: 25742714 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Breast | 8.3 | Low |
| Stomach | 15.7 | Medium |
| Pancreas | 6.2 | Low |
| Skin | 20.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (Lung) | 18.4 | High expression |
| MCF7 (Breast) | 9.8 | Moderate expression |
| HeLa (Cervical) | 14.2 | Moderate expression |
| K562 (Leukemia) | 3.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | Rare | Unknown functional impact |
| c.1246G>A (p.Gly416Arg) | Missense | Rare | Potential loss of function |
| c.1570_1571insA | Frameshift | Rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of function, potentially impairing DNA repair.
Gain of Function (GOF)
Amplification and overexpression in cancers suggest a gain-of-function role in tumorigenesis.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • nucleus (GO:0005634) |
| • cytoplasm (GO:0005737) | • DNA damage response (GO:0006974) |
| • identical protein binding (GO:0042802) |
Pathways
• p53 signaling pathway
• DNA damage response
• ATM signaling
Protein Summary
The TRIM29 protein contains a RING finger domain, B-box, and coiled-coil region, characteristic of TRIM family members. It localizes to the nucleus and cytoplasm and interacts with p53, modulating its stability and transcriptional activity. TRIM29 is involved in homologous recombination repair and immune signaling through NF-κB. Its expression is frequently altered in cancers, influencing cell proliferation, apoptosis, and chemoresistance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM29 Knockout HEK293 Cell Line | EDJ-KQ8110 | Human | 23650 | Details Get a Quote |
| TRIM29 Knockout A-549 Cell Line | EDJ-KQ33984 | Human | 23650 | Details Get a Quote |
| TRIM29 Knockout HeLa Cell Line | EDJ-KQ33985 | Human | 23650 | Details Get a Quote |
| TRIM29 Knockout HCT 116 Cell Line | EDJ-KQ72735 | Human | 23650 | Details Get a Quote |
