TRIM26: Tripartite Motif Containing 26
A RING-type E3 ubiquitin ligase involved in innate immunity and antiviral response
Gene Information Card
| Symbol | TRIM26 |
|---|---|
| Full Name | Tripartite Motif Containing 26 |
| Gene Type | protein-coding |
| Chromosomal Location | 6p22.1 |
| NCBI Gene ID | 7726 ncbi.nlm.nih.gov/gene/7726 |
| Ensembl ID | ENSG00000112419 |
| UniProt ID | Q12899 |
| OMIM ID | 606331 |
| HGNC ID | 12362 |
| Aliases | RNF95, ZNF173, RING finger protein 95 |
Description
TRIM26 (Tripartite Motif Containing 26) encodes a member of the tripartite motif (TRIM) family, characterized by a RING finger domain, B-box zinc finger, and coiled-coil region. The protein functions as an E3 ubiquitin ligase, playing a key role in innate immune signaling by modulating interferon regulatory factors and antiviral responses. TRIM26 is also implicated in cancer through regulation of p53 and other tumor suppressors.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | TRIM26 overexpression promotes tumor growth via ubiquitination and degradation of p53 | PMID: 28793258 |
| Nasopharyngeal carcinoma | TRIM26 suppresses tumorigenesis by enhancing IRF3-mediated interferon signaling | PMID: 27307487 |
| Viral infections (Influenza A) | TRIM26 restricts influenza A virus replication by targeting viral nucleoprotein for degradation | PMID: 31534019 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Lung | 8.3 | Low |
| Spleen | 6.1 | Low |
| Testis | 4.7 | Low |
| Kidney | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line |
| A549 | 9.8 | Lung adenocarcinoma cell line |
| HEK293 | 7.4 | Embryonic kidney cell line |
| HeLa | 5.1 | Cervical cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Pro34Leu) | Missense | 0.01% | Unknown functional impact |
| c.256G>A (p.Gly86Arg) | Missense | 0.005% | Potential loss of ubiquitin ligase activity |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in the RING domain may impair E3 ligase activity, reducing antiviral signaling.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• RIG-I-like receptor signaling pathway (KEGG: hsa04622)
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
• Innate Immune System (Reactome: R-HSA-168249)
Protein Summary
TRIM26 is a 539-amino acid protein (UniProt Q12899) with a molecular weight of approximately 60 kDa. It contains an N-terminal RING finger domain (required for E3 ubiquitin ligase activity), two B-box zinc fingers, a coiled-coil region, and a C-terminal SPRY domain. The protein localizes to the cytoplasm and is involved in ubiquitination and degradation of target proteins, including viral components and host regulators such as p53 and IRF3.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM26 Knockout HEK293 Cell Line | EDJ-KQ2391 | Human | 7726 | Details Get a Quote |
| TRIM26 Knockout A-549 Cell Line | EDJ-KQ22876 | Human | 7726 | Details Get a Quote |
| TRIM26 Knockout HCT 116 Cell Line | EDJ-KQ22877 | Human | 7726 | Details Get a Quote |
| TRIM26 Knockout HeLa Cell Line | EDJ-KQ22878 | Human | 7726 | Details Get a Quote |
