TRIM23: Tripartite Motif Containing 23
A GTPase-activating protein involved in autophagy, viral restriction, and cancer
Gene Information Card
| Symbol | TRIM23 |
|---|---|
| Full Name | Tripartite Motif Containing 23 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q12.3 |
| NCBI Gene ID | 373 ncbi.nlm.nih.gov/gene/373 |
| Ensembl ID | ENSG00000113595 |
| UniProt ID | P36406 |
| OMIM ID | 602564 |
| HGNC ID | 12312 |
| Aliases | ARF1BP1, RNF46, ARFD1 |
Description
TRIM23 (tripartite motif containing 23) encodes a member of the tripartite motif (TRIM) family. The protein contains a RING finger domain, B-box, coiled-coil region, and a C-terminal ADP-ribosylation factor (ARF) domain. It functions as a GTPase-activating protein (GAP) for ARF1 and is involved in autophagy, vesicular trafficking, and innate immunity. TRIM23 also acts as an E3 ubiquitin ligase and plays a role in restricting viral infections, including HIV-1 and influenza A virus.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | TRIM23 overexpression or mutation may alter autophagy and vesicular trafficking, promoting tumorigenesis. | COSMIC; literature |
| Viral infections (HIV-1, influenza A) | TRIM23 restricts viral replication via autophagy-dependent mechanisms and ARF1 GAP activity. | PubMed; UniProt |
| Neurodegenerative disorders | Impaired TRIM23-mediated autophagy may contribute to protein aggregation. | Inferred from function |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
| Spleen | 7.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Embryonic kidney |
| HeLa | 8.5 | Cervical carcinoma |
| A549 | 7.2 | Lung carcinoma |
| K562 | 6.8 | Leukemia |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Cys) | Missense | <0.01% | Unknown; reported in COSMIC |
| c.1420G>A (p.Glu474Lys) | Missense | <0.01% | Unknown; reported in COSMIC |
| c.1876_1877insA (p.Thr626Asnfs*5) | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Thr626Asnfs*5) likely disrupt the ARF domain, impairing GAP activity and autophagy.
Gain of Function (GOF)
Not well characterized; some missense variants may alter substrate specificity.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • GTPase activator activity | • zinc ion binding |
| • protein ubiquitination | • autophagy |
| • viral process | • intracellular protein transport |
| • innate immune response |
Pathways
• Autophagy
• Vesicle-mediated transport
• ARF GTPase cycle
• Innate immune system
Protein Summary
TRIM23 is a 574-amino acid protein with a tripartite motif (RING, B-box, coiled-coil) and a C-terminal ARF domain. It acts as a GTPase-activating protein for ARF1, regulating vesicular trafficking. As an E3 ubiquitin ligase, it promotes autophagic degradation of viral components. TRIM23 is broadly expressed and implicated in cancer, viral restriction, and autophagy-related disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM23 Knockout HEK293 Cell Line | EDJ-KQ4076 | Human | 373 | Details Get a Quote |
| TRIM23 Knockout A-549 Cell Line | EDJ-KQ26444 | Human | 373 | Details Get a Quote |
| TRIM23 Knockout HCT 116 Cell Line | EDJ-KQ26445 | Human | 373 | Details Get a Quote |
| TRIM23 Knockout HeLa Cell Line | EDJ-KQ26446 | Human | 373 | Details Get a Quote |
