TRIM17: Tripartite Motif Containing 17
A RING-type E3 ubiquitin ligase involved in apoptosis, autophagy, and neuronal development.
Gene Information Card
| Symbol | TRIM17 |
|---|---|
| Full Name | Tripartite Motif Containing 17 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q42.13 |
| NCBI Gene ID | 51127 ncbi.nlm.nih.gov/gene/51127 |
| Ensembl ID | ENSG00000162931 |
| UniProt ID | Q9Y577 |
| OMIM ID | 606560 |
| HGNC ID | 13430 |
| Aliases | RNF16, TERF |
Description
TRIM17 (Tripartite Motif Containing 17) encodes a member of the tripartite motif (TRIM) family. The protein contains a RING finger domain, B-box type 1 and type 2, and a coiled-coil region. It functions as an E3 ubiquitin ligase and is implicated in the regulation of apoptosis, autophagy, and neuronal differentiation. TRIM17 is expressed in the brain and testis, and its dysregulation has been linked to neuroblastoma and other cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neuroblastoma | TRIM17 overexpression may promote cell survival by inhibiting apoptosis and autophagy. | COSMIC; PubMed studies |
| Testicular germ cell tumors | Altered expression observed; potential role in spermatogenesis regulation. | NCBI Gene; UniProt |
| Breast cancer | Differential expression reported; mechanism unclear. | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Cerebral cortex | 8.2 | Low |
| Cerebellum | 6.7 | Low |
| Heart | 2.1 | Not detected |
| Liver | 1.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.3 | High expression; used in functional studies |
| HEK293 (embryonic kidney) | 4.8 | Moderate expression |
| HeLa (cervical carcinoma) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Pro125Leu) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.682G>A (p.Glu228Lys) | Missense | <0.01% | Unknown; reported in COSMIC |
| c.1003_1004insA (p.Thr335Asnfs*2) | Frameshift | Not reported | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift or nonsense mutations predicted to truncate the protein, disrupting RING domain and ubiquitin ligase activity.
Gain of Function (GOF)
Not well characterized; some missense variants may alter substrate specificity.
Dominant Negative (DN)
No evidence currently available.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
• Autophagy - animal (KEGG: hsa04140)
• Apoptosis (KEGG: hsa04210)
Protein Summary
TRIM17 is a 477-amino acid protein with a molecular weight of approximately 54 kDa. It contains a RING-type zinc finger domain (residues 16-54) essential for E3 ubiquitin ligase activity, two B-box domains (residues 93-136 and 167-210), and a coiled-coil region (residues 218-260). The protein localizes to the cytoplasm and nucleus. TRIM17 interacts with other TRIM family members and substrates to regulate protein degradation, apoptosis, and autophagy. Its expression is enriched in the brain and testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM17 Knockout HEK293 Cell Line | EDJ-KQ3275 | Human | 51127 | Details Get a Quote |
| TRIM17 Knockout HeLa Cell Line | EDJ-KQ56233 | Human | 51127 | Details Get a Quote |
| TRIM17 Knockout A-549 Cell Line | EDJ-KQ64723 | Human | 51127 | Details Get a Quote |
| TRIM17 Knockout HCT 116 Cell Line | EDJ-KQ73168 | Human | 51127 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
