TRERF1 Transcriptional Regulating Factor 1
A zinc finger transcription factor involved in development and cancer
Gene Information Card
| Symbol | TRERF1 |
|---|---|
| Full Name | Transcriptional Regulating Factor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 2p13.2 |
| NCBI Gene ID | 55809 ncbi.nlm.nih.gov/gene/55809 |
| Ensembl ID | ENSG00000115956 |
| UniProt ID | Q96PN7 |
| OMIM ID | 610322 |
| HGNC ID | 30873 |
| Aliases | RREB1, ZFP, ZNF354C, HRIHFB2072 |
Description
TRERF1 (Transcriptional Regulating Factor 1) encodes a zinc finger transcription factor that binds to Ras-responsive elements (RRE) and regulates gene expression. It is involved in cell differentiation, proliferation, and development. The protein contains multiple C2H2-type zinc finger domains and a leucine zipper motif. TRERF1 is implicated in several cancers and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | TRERF1 overexpression may promote androgen receptor signaling | PMID: 23431171 |
| Breast cancer | Altered expression linked to poor prognosis | PMID: 25686104 |
| Colorectal cancer | Mutations and copy number alterations observed | COSMIC analysis |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Prostate | 12.8 | Medium |
| Breast | 8.5 | Low |
| Colon | 6.3 | Low |
| Brain | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| LNCaP (prostate cancer) | 18.5 | High expression |
| MCF7 (breast cancer) | 11.2 | Moderate expression |
| HCT116 (colorectal cancer) | 9.8 | Moderate expression |
| HEK293 (embryonic kidney) | 4.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | <0.1% | Unknown functional impact |
| c.567_568del (p.Glu190fs) | Frameshift | <0.1% | Predicted loss of function |
| c.789G>A (p.Trp263*) | Nonsense | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of function.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| • zinc ion binding | • nucleus |
| • regulation of transcription by RNA polymerase II |
Pathways
• Ras signaling pathway
• Androgen receptor signaling pathway
Protein Summary
TRERF1 is a 794-amino acid zinc finger transcription factor that localizes to the nucleus. It contains 13 C2H2-type zinc fingers and a leucine zipper domain. The protein binds to Ras-responsive elements (RRE) and modulates transcription of target genes involved in cell growth and differentiation. TRERF1 is expressed in multiple tissues, with highest levels in testis and prostate. It is implicated in prostate, breast, and colorectal cancers through altered expression and mutations.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRERF1 Knockout HEK293 Cell Line | EDJ-KQ15914 | Human | 55809 | Details Get a Quote |
| TRERF1 Knockout HCT 116 Cell Line | EDJ-KQ46920 | Human | 55809 | Details Get a Quote |
| TRERF1 Knockout HeLa Cell Line | EDJ-KQ46921 | Human | 55809 | Details Get a Quote |
| TRERF1 Knockout A-549 Cell Line | EDJ-KQ49138 | Human | 55809 | Details Get a Quote |
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