TPPP2: Tubulin Polymerization Promoting Protein Family Member 2
A microtubule-associated protein involved in cytoskeletal dynamics and potential implications in neurological disorders and cancer.
Gene Information Card
| Symbol | TPPP2 |
|---|---|
| Full Name | Tubulin Polymerization Promoting Protein Family Member 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q11.2 |
| NCBI Gene ID | 122664 ncbi.nlm.nih.gov/gene/122664 |
| Ensembl ID | ENSG00000100804 |
| UniProt ID | Q8IUR5 |
| OMIM ID | 617905 |
| HGNC ID | 25803 |
| Aliases | p25gamma, p25-2, TPPP/p25 family member 2 |
Description
TPPP2 encodes a member of the tubulin polymerization-promoting protein (TPPP) family. The protein binds to microtubules and promotes their polymerization and bundling, playing a role in cytoskeletal organization. It is expressed predominantly in the brain and testis, and its dysregulation has been implicated in neurodegenerative conditions and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Multiple Sclerosis | Altered TPPP2 expression may contribute to oligodendrocyte dysfunction and demyelination. | NCBI Gene, PubMed |
| Glioblastoma | Overexpression of TPPP2 has been observed in glioblastoma cell lines, potentially affecting microtubule dynamics and cell proliferation. | COSMIC, PubMed |
| Prostate Cancer | TPPP2 expression changes have been reported in prostate cancer tissues, suggesting a role in tumor progression. | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.3 | Medium |
| Heart | 1.2 | Low |
| Liver | 0.5 | Not detected |
| Kidney | 0.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.2 | High expression |
| U87MG (glioblastoma) | 10.1 | Medium expression |
| HeLa (cervical carcinoma) | 2.3 | Low expression |
| HEK293 (embryonic kidney) | 1.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.197C>T (p.Pro66Leu) | Missense | <0.01% | Unknown; predicted benign by in silico tools |
| c.304G>A (p.Gly102Arg) | Missense | <0.01% | Unknown; predicted possibly damaging |
| c.421_423del (p.Lys141del) | In-frame deletion | <0.01% | May affect microtubule binding |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in TPPP2.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in TPPP2.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in TPPP2.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • microtubule binding (GO:0008017) |
| • microtubule polymerization (GO:0046785) | • cytoplasm (GO:0005737) |
| • microtubule (GO:0005874) |
Pathways
• Microtubule cytoskeleton organization (Reactome: R-HSA-190840)
• Formation of tubulin folding intermediates by CCT/TriC (Reactome: R-HSA-389958)
Protein Summary
TPPP2 is a 180-amino acid protein that belongs to the TPPP family. It localizes to the cytoplasm and associates with microtubules, promoting their polymerization and bundling. The protein contains a conserved p25 domain essential for microtubule interaction. TPPP2 is highly expressed in brain and testis, and its expression is altered in neurological disorders and cancers, suggesting a role in cell division and differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TPPP2 Knockout HEK293 Cell Line | EDJ-KQ8158 | Human | 122664 | Details Get a Quote |
| TPPP2 Knockout HeLa Cell Line | EDJ-KQ58102 | Human | 122664 | Details Get a Quote |
| TPPP2 Knockout A-549 Cell Line | EDJ-KQ66590 | Human | 122664 | Details Get a Quote |
| TPPP2 Knockout HCT 116 Cell Line | EDJ-KQ75006 | Human | 122664 | Details Get a Quote |
