TP53TG3D Gene - TP53 Target 3D
A p53-inducible gene with potential roles in cancer and cellular stress response
Gene Information Card
| Symbol | TP53TG3D |
|---|---|
| Full Name | TP53 target 3D |
| Gene Type | protein coding |
| Chromosomal Location | 16p11.2 |
| NCBI Gene ID | 10797615 ncbi.nlm.nih.gov/gene/10797615 |
| Ensembl ID | ENSG00000204394 |
| UniProt ID | Q96ST3 |
| OMIM ID | Not available |
| HGNC ID | HGNC:33755 |
| Aliases | TP53TG3, TP53TG3B, TP53TG3C |
Description
TP53TG3D is a protein-coding gene located on chromosome 16p11.2. It is part of a gene family that is induced by the tumor suppressor p53, suggesting a role in p53-mediated cellular stress responses. The gene is expressed in various tissues and has been implicated in cancer biology, though its exact function remains under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential involvement in p53 pathway; altered expression may affect tumor suppression | Inferred from p53 inducibility and expression studies |
| Lung cancer | Overexpression observed in some studies; may influence cell proliferation | Limited evidence from expression profiling |
| Colorectal cancer | Differential expression linked to p53 status | Inferred from p53 pathway studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Low expression |
| Bone marrow | Not available | Low expression |
| Lung | Not available | Moderate expression |
| Colon | Not available | Moderate expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | Not available | p53-inducible expression |
| HCT116 (colorectal carcinoma) | Not available | p53-dependent expression |
| MCF7 (breast carcinoma) | Not available | Low basal expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| Not well characterized | Not available | Not available | Not available |
Mutation functional classification
Loss of Function (LOF)
No specific loss-of-function mutations reported.
Gain of Function (GOF)
No specific gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • Molecular function: Not yet assigned | • Biological process: cellular response to stress (inferred from p53 inducibility) |
| • Cellular component: Not yet assigned |
Pathways
• p53 signaling pathway (inferred from p53 target gene status)
Protein Summary
The TP53TG3D protein is predicted to be a small, possibly transmembrane or secreted protein, but its exact function is unknown. It is induced by p53 and may participate in growth arrest or apoptosis. Further studies are needed to characterize its cellular role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TP53TG3D Knockout HEK293 Cell Line | EDJ-KQ15891 | Human | 729264 | Details Get a Quote |
| TP53TG3D Knockout A-549 Cell Line | EDJ-KQ49114 | Human | 729264 | Details Get a Quote |
| TP53TG3D Knockout HeLa Cell Line | EDJ-KQ60742 | Human | 729264 | Details Get a Quote |
| TP53TG3D Knockout HCT 116 Cell Line | EDJ-KQ77569 | Human | 729264 | Details Get a Quote |
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