TP53TG3C: TP53 Target Gene 3C
A p53-regulated gene with potential roles in cellular stress response and tumor suppression
Gene Information Card
| Symbol | TP53TG3C |
|---|---|
| Full Name | TP53 target gene 3C |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 729540 ncbi.nlm.nih.gov/gene/729540 |
| Ensembl ID | ENSG00000214360 |
| UniProt ID | Q5JXB2 |
| OMIM ID | 614505 |
| HGNC ID | 37221 |
| Aliases | TP53TG3, TP53TG3A, TP53TG3B |
Description
TP53TG3C is a protein-coding gene located on chromosome 16p13.3. It is a member of the TP53 target gene family, which are regulated by the tumor suppressor p53. The gene is involved in cellular stress responses and may play a role in growth suppression and apoptosis. Alternative splicing generates multiple transcript variants.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential p53-mediated tumor suppression; altered expression may contribute to oncogenesis | Limited; inferred from p53 pathway studies (NCBI Gene, OMIM) |
| Li-Fraumeni syndrome | Indirect; p53 pathway disruption may affect TP53TG3C regulation | Not directly associated; p53 mutations in Li-Fraumeni may impact target genes (OMIM) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.1 | Low |
| Thyroid | 1.5 | Low |
| Prostate | 1.2 | Low |
| Breast | 0.8 | Not detected |
| Lung | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.3 | Low expression |
| HeLa | 0.1 | Not detected |
| MCF7 | 0.2 | Not detected |
| A549 | 0.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown; likely benign |
| c.100C>T | missense | <0.01% | Unknown; likely benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in TP53TG3C.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) | • positive regulation of apoptotic process (GO:0043065) |
Pathways
• p53 signaling pathway (KEGG: hsa04115)
• Apoptosis (Reactome: R-HSA-109581)
Protein Summary
The TP53TG3C protein is a small, poorly characterized protein of 112 amino acids. It is predicted to localize to the cytoplasm and nucleus. Its function is not fully elucidated, but it is thought to participate in p53-mediated apoptosis and cell cycle regulation. No enzymatic activity has been assigned.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TP53TG3C Knockout HEK293 Cell Line | EDJ-KQ15890 | Human | 653550 | Details Get a Quote |
| TP53TG3C Knockout HeLa Cell Line | EDJ-KQ60652 | Human | 653550 | Details Get a Quote |
| TP53TG3C Knockout A-549 Cell Line | EDJ-KQ69125 | Human | 653550 | Details Get a Quote |
| TP53TG3C Knockout HCT 116 Cell Line | EDJ-KQ77477 | Human | 653550 | Details Get a Quote |
