TP53TG3B: TP53 Target Gene 3B
A p53-regulated gene with potential roles in cellular stress response and cancer biology
Gene Information Card
| Symbol | TP53TG3B |
|---|---|
| Full Name | TP53 target gene 3B |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 729262 ncbi.nlm.nih.gov/gene/729262 |
| Ensembl ID | ENSG00000204149 |
| UniProt ID | Q96BZ9 |
| OMIM ID | Not available |
| HGNC ID | HGNC:33731 |
| Aliases | TP53TG3, TP53TG3A, TP53TG3C, TP53TG3D |
Description
TP53TG3B is a protein-coding gene located on chromosome 16p13.3. It is a member of the TP53TG3 family, which is regulated by the tumor suppressor p53 (TP53). The gene is involved in cellular stress responses and has been implicated in various cancers. Expression data from the Genotype-Tissue Expression (GTEx) project indicate tissue-specific patterns, with highest levels in testis and certain cancer cell lines.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | p53 pathway dysregulation; TP53TG3B overexpression may contribute to tumorigenesis | Limited; inferred from p53 regulation and expression in cancer cell lines (COSMIC) |
| Testicular germ cell tumors | High expression in testis suggests potential role in germ cell biology | Expression data (GTEx); no direct mechanistic evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Thyroid | 3.2 | Low |
| Prostate | 2.1 | Low |
| Breast | 1.8 | Low |
| Lung | 1.5 | Low |
| Colon | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.4 | Embryonic kidney; moderate expression |
| HeLa | 6.7 | Cervical cancer; moderate expression |
| MCF7 | 4.3 | Breast cancer; low expression |
| A549 | 3.9 | Lung cancer; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown; rare variant (COSMIC) |
| c.100C>T | missense | <0.01% | Unknown; rare variant (COSMIC) |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function mutations in TP53TG3B.
Gain of Function (GOF)
No documented gain-of-function mutations in TP53TG3B.
Dominant Negative (DN)
No documented dominant-negative mutations in TP53TG3B.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) |
Pathways
• p53 signaling pathway (Reactome: R-HSA-3700989)
Protein Summary
The TP53TG3B protein (UniProt Q96BZ9) is a 154-amino acid polypeptide with no characterized domains. It is predicted to localize to the cytoplasm and nucleus. Its function remains largely unknown, but it is transcriptionally regulated by p53, suggesting a role in stress-induced cellular responses. No enzymatic activity or structural motifs have been experimentally validated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TP53TG3B Knockout HEK293 Cell Line | EDJ-KQ15097 | Human | 729355 | Details Get a Quote |
| TP53TG3B Knockout HeLa Cell Line | EDJ-KQ60745 | Human | 729355 | Details Get a Quote |
| TP53TG3B Knockout A-549 Cell Line | EDJ-KQ69214 | Human | 729355 | Details Get a Quote |
| TP53TG3B Knockout HCT 116 Cell Line | EDJ-KQ77572 | Human | 729355 | Details Get a Quote |
