TP53INP2: Tumor Protein p53 Inducible Nuclear Protein 2
A stress-responsive nuclear protein involved in autophagy, apoptosis, and metabolic regulation
Gene Information Card
| Symbol | TP53INP2 |
|---|---|
| Full Name | Tumor Protein p53 Inducible Nuclear Protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 20q11.22 |
| NCBI Gene ID | 58476 ncbi.nlm.nih.gov/gene/58476 |
| Ensembl ID | ENSG00000101204 |
| UniProt ID | Q8IXH7 |
| OMIM ID | 614504 |
| HGNC ID | 16113 |
| Aliases | DOR, PINP2, TP53INP2 |
Description
TP53INP2 (Tumor Protein p53 Inducible Nuclear Protein 2) is a stress-responsive gene encoding a nuclear protein that plays a dual role in autophagy and apoptosis. It is induced by p53 and other stress signals, and functions as a coactivator of transcription factors involved in metabolic and autophagic pathways. TP53INP2 is also implicated in cancer progression and metabolic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression affects autophagy and apoptosis; may promote or suppress tumor growth depending on context | PMID: 21804531 |
| Metabolic syndrome | Regulation of autophagy in adipose tissue and liver influences insulin sensitivity and lipid metabolism | PMID: 22960638 |
| Neurodegenerative diseases | Dysregulation of autophagy linked to protein aggregation; TP53INP2 modulates autophagic flux | PMID: 25684226 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 12.5 | Medium |
| Liver | 8.3 | Medium |
| Brain | 6.1 | Low |
| Heart | 4.7 | Low |
| Skeletal muscle | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| HEK293 | 10.8 | Embryonic kidney cells |
| HepG2 | 9.5 | Hepatocellular carcinoma |
| MCF7 | 7.3 | Breast cancer cells |
| SH-SY5Y | 5.1 | Neuroblastoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Potential loss of start codon; functional impact unknown |
| c.215C>T (p.Pro72Leu) | Missense | 0.02% | May alter protein stability; not well characterized |
| c.487G>A (p.Gly163Arg) | Missense | <0.01% | Rare variant; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in TP53INP2.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • autophagy (GO:0006914) | • apoptotic process (GO:0006915) |
| • nucleus (GO:0005634) | • transcription coactivator activity (GO:0003713) |
| • identical protein binding (GO:0042802) |
Pathways
• Autophagy (hsa04140)
• p53 signaling pathway (hsa04115)
• Regulation of autophagy (hsa04140)
Protein Summary
TP53INP2 is a 237-amino acid nuclear protein that contains a conserved DOR domain. It acts as a transcriptional coactivator for PPARγ and other nuclear receptors, promoting autophagy by facilitating the formation of autophagosomes. It also interacts with p53 to modulate apoptosis. The protein is ubiquitously expressed with highest levels in adipose tissue and liver.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TP53INP2 Knockout HEK293 Cell Line | EDJ-KQ15889 | Human | 58476 | Details Get a Quote |
| TP53INP2 Knockout A-549 Cell Line | EDJ-KQ49111 | Human | 58476 | Details Get a Quote |
| TP53INP2 Knockout HCT 116 Cell Line | EDJ-KQ49112 | Human | 58476 | Details Get a Quote |
| TP53INP2 Knockout HeLa Cell Line | EDJ-KQ49113 | Human | 58476 | Details Get a Quote |
