TP53I3
Tumor Protein p53 Inducible Protein 3
Gene Information Card
| Symbol | TP53I3 |
|---|---|
| Full Name | Tumor Protein p53 Inducible Protein 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 2p23.3 |
| NCBI Gene ID | 9540 ncbi.nlm.nih.gov/gene/9540 |
| Ensembl ID | ENSG00000115129 |
| UniProt ID | Q53FA7 |
| OMIM ID | 605171 |
| HGNC ID | 11998 |
| Aliases | PIG3 |
Description
TP53I3 (tumor protein p53 inducible protein 3) is a protein-coding gene that encodes a pro-apoptotic protein induced by the tumor suppressor p53 in response to DNA damage. The protein localizes to the cytoplasm and nucleus and is involved in the generation of reactive oxygen species (ROS) and the induction of apoptosis. TP53I3 is also known as PIG3 (p53-induced gene 3) and plays a role in the cellular response to genotoxic stress.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | TP53I3 expression is regulated by p53; loss of p53 function leads to reduced TP53I3 expression and impaired apoptosis. | NCBI Gene, PubMed: 10652319 |
| Colorectal cancer | TP53I3 is upregulated in response to DNA damage; mutations in p53 pathway may alter TP53I3 expression. | NCBI Gene, PubMed: 10652319 |
| Lung cancer | TP53I3 expression is associated with p53 status; potential role in tumor suppression. | NCBI Gene, PubMed: 10652319 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
| Breast | 0.0 | Not detected |
| Colon | 0.0 | Not detected |
| Esophagus | 0.0 | Not detected |
| Heart | 0.0 | Not detected |
| Kidney | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
| Lung | 0.0 | Not detected |
| Ovary | 0.0 | Not detected |
| Pancreas | 0.0 | Not detected |
| Prostate | 0.0 | Not detected |
| Skin | 0.0 | Not detected |
| Small intestine | 0.0 | Not detected |
| Spleen | 0.0 | Not detected |
| Stomach | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
| Thyroid | 0.0 | Not detected |
| Urinary bladder | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A-431 | 0.0 | Not detected |
| HepG2 | 0.0 | Not detected |
| K-562 | 0.0 | Not detected |
| MCF7 | 0.0 | Not detected |
| U-2 OS | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | Unknown | Potential loss of function |
| c.2T>C | Missense | Unknown | Potential loss of function |
Mutation functional classification
Loss of Function (LOF)
Mutations that disrupt the pro-apoptotic function of TP53I3 may impair p53-mediated apoptosis.
Gain of Function (GOF)
No known gain-of-function mutations reported.
Dominant Negative (DN)
No known dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • apoptotic process (GO:0006915) | • cellular response to DNA damage stimulus (GO:0006974) |
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) |
Pathways
• p53 signaling pathway (Reactome: R-HSA-3700989)
• Intrinsic pathway for apoptosis (Reactome: R-HSA-109606)
Protein Summary
TP53I3 encodes a 232-amino acid protein with a molecular weight of approximately 26 kDa. The protein contains a putative NAD(P)H quinone oxidoreductase domain and is involved in the generation of reactive oxygen species (ROS) leading to apoptosis. It is induced by p53 in response to DNA damage and localizes to both the cytoplasm and nucleus.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TP53I3 Knockout HEK293 Cell Line | EDJ-KQ6637 | Human | 9540 | Details Get a Quote |
| TP53I3 Knockout HeLa Cell Line | EDJ-KQ29552 | Human | 9540 | Details Get a Quote |
| TP53I3 Knockout A-549 Cell Line | EDJ-KQ30899 | Human | 9540 | Details Get a Quote |
| TP53I3 Knockout HCT 116 Cell Line | EDJ-KQ30900 | Human | 9540 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
