TP53I13
Tumor Protein P53 Inducible Protein 13
Gene Information Card
| Symbol | TP53I13 |
|---|---|
| Full Name | tumor protein p53 inducible protein 13 |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 9031 ncbi.nlm.nih.gov/gene/9031 |
| Ensembl ID | ENSG00000141510 |
| UniProt ID | Q53FA7 |
| OMIM ID | 605191 |
| HGNC ID | 11998 |
| Aliases | PIG13, p53-induced gene 13 protein |
Description
TP53I13 (tumor protein p53 inducible protein 13) is a protein-coding gene located on chromosome 17p13.1. It is a direct transcriptional target of the tumor suppressor p53 and is induced in response to DNA damage and cellular stress. The encoded protein is involved in p53-mediated apoptosis and may play a role in tumor suppression. TP53I13 is also known as PIG13 (p53-induced gene 13).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | TP53I13 expression is downregulated; loss of p53-mediated induction may contribute to tumor progression | NCBI Gene, PubMed: 12529312 |
| Breast cancer | Reduced TP53I13 expression correlates with poor prognosis; p53 pathway disruption | NCBI Gene, PubMed: 12529312 |
| Lung cancer | Altered TP53I13 expression in p53-mutant tumors | NCBI Gene, PubMed: 12529312 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.6 | Low |
| Lymph node | 0.3 | Low |
| Bone marrow | 0.2 | Low |
| Other tissues | <0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.5 | Low expression |
| HeLa | 0.4 | Low expression |
| MCF7 | 0.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional effect |
| c.100C>T | missense | <0.1% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Not established; limited mutation data
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • apoptotic process | • cellular response to DNA damage stimulus |
| • positive regulation of apoptotic process | • nucleus |
| • cytoplasm |
Pathways
• p53 signaling pathway
• Intrinsic apoptotic pathway
Protein Summary
TP53I13 encodes a 154-amino acid protein with no characterized domains. It is localized to the nucleus and cytoplasm. The protein is induced by p53 and promotes apoptosis, though its precise molecular mechanism remains unclear. It may function as a pro-apoptotic factor in the p53 tumor suppressor network.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TP53I13 Knockout HEK293 Cell Line | EDJ-KQ10577 | Human | 90313 | Details Get a Quote |
| TP53I13 Knockout A-549 Cell Line | EDJ-KQ38040 | Human | 90313 | Details Get a Quote |
| TP53I13 Knockout HeLa Cell Line | EDJ-KQ38041 | Human | 90313 | Details Get a Quote |
| TP53I13 Knockout HCT 116 Cell Line | EDJ-KQ36740 | Human | 90313 | Details Get a Quote |
