TP53I11
Tumor Protein p53 Inducible Protein 11
Gene Information Card
| Symbol | TP53I11 |
|---|---|
| Full Name | tumor protein p53 inducible protein 11 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p11.2 |
| NCBI Gene ID | 9537 ncbi.nlm.nih.gov/gene/9537 |
| Ensembl ID | ENSG00000175279 |
| UniProt ID | O14684 |
| OMIM ID | 609265 |
| HGNC ID | 18004 |
| Aliases | PIG11, PRKCA, TP53I11 |
Description
TP53I11 (tumor protein p53 inducible protein 11) is a protein-coding gene located on chromosome 11p11.2. It is induced by the tumor suppressor p53 and plays a role in apoptosis and cell cycle regulation. The gene is also known as PIG11 (p53-induced gene 11) and PRKCA (protein kinase C alpha).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | TP53I11 is a p53 target; loss of p53 function reduces TP53I11 expression, impairing apoptosis. | NCBI Gene, COSMIC |
| Colorectal cancer | Downregulation of TP53I11 observed in tumors; associated with poor prognosis. | COSMIC, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Thyroid | 8.7 | Low |
| Lung | 6.2 | Low |
| Brain | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| A549 | 9.8 | Lung cancer cell line |
| MCF7 | 7.5 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287G>A (p.Arg96His) | Missense | Rare | Unknown functional effect |
| c.421C>T (p.Arg141Trp) | Missense | Rare | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Not established; limited data.
Gain of Function (GOF)
Not established.
Dominant Negative (DN)
Not established.
View complete mutation data：
Gene Ontology (GO)
| • apoptotic process | • positive regulation of apoptotic process |
| • protein binding |
Pathways
• p53 signaling pathway
• Apoptosis
Protein Summary
The TP53I11 protein (UniProt O14684) is a 154-amino acid protein induced by p53. It localizes to the cytoplasm and nucleus and is involved in promoting apoptosis. Its exact molecular function remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TP53I11 Knockout HEK293 Cell Line | EDJ-KQ6629 | Human | 9537 | Details Get a Quote |
| TP53I11 Knockout A-549 Cell Line | EDJ-KQ30875 | Human | 9537 | Details Get a Quote |
| TP53I11 Knockout HCT 116 Cell Line | EDJ-KQ30876 | Human | 9537 | Details Get a Quote |
| TP53I11 Knockout HeLa Cell Line | EDJ-KQ30877 | Human | 9537 | Details Get a Quote |
