TNRC6C
Trinucleotide Repeat Containing Adaptor 6C
Gene Information Card
| Symbol | TNRC6C |
|---|---|
| Full Name | Trinucleotide Repeat Containing Adaptor 6C |
| Gene Type | Protein coding |
| Chromosomal Location | 17q25.3 |
| NCBI Gene ID | 57690 ncbi.nlm.nih.gov/gene/57690 |
| Ensembl ID | ENSG00000178605 |
| UniProt ID | Q9HCJ0 |
| OMIM ID | 610741 |
| HGNC ID | 29182 |
| Aliases | GW182, TNRC6C, KIAA1582 |
Description
TNRC6C encodes a member of the GW182 protein family, which are essential components of the miRNA-induced silencing complex (miRISC). These proteins contain multiple glycine-tryptophan (GW) repeats and interact with Argonaute proteins to mediate mRNA deadenylation and translational repression. TNRC6C is involved in post-transcriptional gene regulation and has been implicated in various cellular processes including proliferation, differentiation, and neurodevelopment.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered TNRC6C expression may disrupt miRNA regulation of oncogenes/tumor suppressors | PMID: 25691885 |
| Breast cancer | TNRC6C copy number alterations and expression changes observed in tumor samples | PMID: 27107036 |
| Neurodevelopmental disorders | TNRC6C variants identified in patients with intellectual disability and autism spectrum disorder | PMID: 30595370 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Medium |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 9.8 | Embryonic kidney cells |
| HeLa | 7.5 | Cervical cancer cells |
| HepG2 | 5.2 | Hepatocellular carcinoma cells |
| SH-SY5Y | 11.3 | Neuroblastoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.01% | Loss of function; predicted to cause nonsense-mediated decay |
| c.567_568insA (p.Glu190fs) | Frameshift | <0.01% | Loss of function; truncated protein |
| c.2345G>A (p.Arg782Gln) | Missense | 0.02% | Unknown; possibly affects protein-protein interactions |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift variants leading to premature stop codons or truncated protein.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • miRNA binding | • mRNA binding |
| • protein binding | • translation repressor activity |
| • cytoplasmic mRNA processing body | • P-body |
Pathways
• miRNA-mediated gene silencing
• RISC complex assembly
• mRNA deadenylation
Protein Summary
TNRC6C is a 1690-amino acid protein containing multiple GW repeats and a C-terminal silencing domain. It localizes to cytoplasmic processing bodies (P-bodies) and interacts with Argonaute proteins to facilitate miRNA-guided mRNA repression. The protein also contains a ubiquitin-associated domain and is subject to post-translational modifications including phosphorylation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TNRC6C Knockout HEK293 Cell Line | EDJ-KQ15086 | Human | 57690 | Details Get a Quote |
| TNRC6C Knockout A-549 Cell Line | EDJ-KQ49096 | Human | 57690 | Details Get a Quote |
| TNRC6C Knockout HCT 116 Cell Line | EDJ-KQ49097 | Human | 57690 | Details Get a Quote |
| TNRC6C Knockout HeLa Cell Line | EDJ-KQ56899 | Human | 57690 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
