TNIP2: TNFAIP3 Interacting Protein 2
A negative regulator of NF-kappa-B signaling involved in inflammation and immune response.
Gene Information Card
| Symbol | TNIP2 |
|---|---|
| Full Name | TNFAIP3 Interacting Protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q35.1 |
| NCBI Gene ID | 79155 ncbi.nlm.nih.gov/gene/79155 |
| Ensembl ID | ENSG00000138684 |
| UniProt ID | Q8NFZ5 |
| OMIM ID | 610669 |
| HGNC ID | 21248 |
| Aliases | ABIN-2, FLJ14886, KIAA1140, TNFAIP3-interacting protein 2 |
Description
TNIP2 (TNFAIP3 Interacting Protein 2) encodes a protein that interacts with TNFAIP3 (A20) and negatively regulates NF-kappa-B activation. It is involved in the inhibition of TNF-induced NF-kappa-B-dependent gene expression and plays a role in immune and inflammatory responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Autoimmune diseases (e.g., systemic lupus erythematosus) | Dysregulation of NF-kappa-B signaling due to altered TNIP2 function | Genetic association studies (PMID: 20383146) |
| Inflammatory bowel disease | Impaired negative regulation of NF-kappa-B leading to chronic inflammation | GWAS (PMID: 23128233) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.3 | Medium |
| Lymph node | 10.8 | Medium |
| Bone marrow | 9.5 | Medium |
| Whole blood | 6.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 14.1 | High expression |
| K-562 | 8.7 | Moderate expression |
| HeLa | 6.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Gly38Arg) | Missense | <0.01% | Unknown functional impact |
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Potential loss of interaction with TNFAIP3 |
Mutation functional classification
Loss of Function (LOF)
Mutations impairing binding to TNFAIP3 or ubiquitin chains, reducing NF-kappa-B inhibition.
Gain of Function (GOF)
Not well characterized; no confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Theoretical; some missense variants may interfere with wild-type protein function.
View complete mutation data：
Gene Ontology (GO)
Pathways
• NF-kappa B signaling pathway (KEGG: hsa04064)
• TNFAIP3-mediated regulation of NF-kappa-B (Reactome: R-HSA-937042)
Protein Summary
TNIP2 (ABIN-2) is a 597-amino acid protein containing a ubiquitin-binding domain and an A20-binding domain. It functions as a negative regulator of NF-kappa-B signaling by recruiting TNFAIP3 to the IKK complex, leading to deubiquitination of signaling intermediates. It is widely expressed in immune tissues and is implicated in autoimmune and inflammatory diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TNIP2 Knockout HEK293 Cell Line | EDJ-KQ11959 | Human | 79155 | Details Get a Quote |
| TNIP2 Knockout HCT 116 Cell Line | EDJ-KQ39253 | Human | 79155 | Details Get a Quote |
| TNIP2 Knockout A-549 Cell Line | EDJ-KQ40497 | Human | 79155 | Details Get a Quote |
| TNIP2 Knockout HeLa Cell Line | EDJ-KQ40499 | Human | 79155 | Details Get a Quote |
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