TNFRSF10D
TNF Receptor Superfamily Member 10d, Decoy Receptor 2 (DcR2)
Gene Information Card
| Symbol | TNFRSF10D |
|---|---|
| Full Name | TNF Receptor Superfamily Member 10d, Decoy with Truncated Death Domain |
| Gene Type | protein-coding |
| Chromosomal Location | 8p21.3 |
| NCBI Gene ID | 8793 ncbi.nlm.nih.gov/gene/8793 |
| Ensembl ID | ENSG00000173530 |
| UniProt ID | Q9UBN6 |
| OMIM ID | 603614 |
| HGNC ID | 11910 |
| Aliases | DcR2, TRAIL-R4, TRUNDD, CD264 |
Description
TNFRSF10D encodes a member of the TNF-receptor superfamily, known as decoy receptor 2 (DcR2) or TRAIL receptor 4. This receptor contains a truncated cytoplasmic death domain and does not induce apoptosis upon ligand binding. It acts as an antagonistic decoy receptor for TRAIL (TNFSF10), inhibiting TRAIL-mediated apoptosis by competing with death receptors DR4 and DR5. The gene is located on chromosome 8p21.3 and is implicated in cancer cell resistance to TRAIL-based therapies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Overexpression of DcR2 blocks TRAIL-induced apoptosis, promoting tumor survival | PMID: 15604205 |
| Non-Small Cell Lung Cancer | DcR2 upregulation correlates with resistance to TRAIL therapy | PMID: 19029980 |
| Breast Cancer | DcR2 expression associated with poor prognosis and evasion of apoptosis | PMID: 21750552 |
| Pancreatic Cancer | DcR2 mediates TRAIL resistance via decoy mechanism | PMID: 23327983 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 2.1 | Low |
| Lymph Node | 1.8 | Low |
| Peripheral Blood | 0.9 | Not detected |
| Colon | 0.5 | Not detected |
| Lung | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.2 | Not detected |
| HeLa | 0.1 | Not detected |
| MCF7 | 0.1 | Not detected |
| A549 | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.202C>T | missense | <0.01% | Unknown |
| c.625G>A | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • tumor necrosis factor-activated receptor activity (GO:0005031) | • apoptotic process (GO:0006915) |
| • signal transduction (GO:0007165) | • integral component of membrane (GO:0016021) |
Pathways
• TRAIL Signaling Pathway (Reactome: R-HSA-75158)
• Apoptosis (KEGG: hsa04210)
Protein Summary
TNFRSF10D (DcR2) is a 386-amino acid type I transmembrane protein with two extracellular cysteine-rich domains and a truncated cytoplasmic death domain. It lacks the functional death domain required for apoptosis induction. DcR2 binds TRAIL (TNFSF10) with high affinity but does not transmit a death signal, thereby acting as a decoy receptor that protects cells from TRAIL-mediated apoptosis. The protein is expressed at low levels in normal tissues but is upregulated in various cancers, contributing to immune evasion and therapy resistance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TNFRSF10D Knockout HEK293 Cell Line | EDJ-KQ6360 | Human | 8793 | Details Get a Quote |
| TNFRSF10D Knockout A-549 Cell Line | EDJ-KQ29010 | Human | 8793 | Details Get a Quote |
| TNFRSF10D Knockout HCT 116 Cell Line | EDJ-KQ30320 | Human | 8793 | Details Get a Quote |
| TNFRSF10D Knockout HeLa Cell Line | EDJ-KQ30321 | Human | 8793 | Details Get a Quote |
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