TNFRSF10C (TNF Receptor Superfamily Member 10c)
Decoy Receptor for TRAIL-Mediated Apoptosis
Gene Information Card
| Symbol | TNFRSF10C |
|---|---|
| Full Name | TNF Receptor Superfamily Member 10c |
| Gene Type | protein-coding |
| Chromosomal Location | 8p21.3 |
| NCBI Gene ID | 8794 ncbi.nlm.nih.gov/gene/8794 |
| Ensembl ID | ENSG00000173578 |
| UniProt ID | O14798 |
| OMIM ID | 603613 |
| HGNC ID | 11905 |
| Aliases | DcR1, TRAIL-R3, TRID, LIT, CD263 |
Description
TNFRSF10C encodes a member of the TNF-receptor superfamily, known as decoy receptor 1 (DcR1) or TRAIL-R3. This receptor contains extracellular TRAIL-binding domains but lacks a functional cytoplasmic death domain, thus it cannot induce apoptosis. It acts as an antagonistic decoy receptor that competes with death receptors DR4 (TNFRSF10A) and DR5 (TNFRSF10B) for TRAIL binding, thereby inhibiting TRAIL-mediated apoptosis. DcR1 is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein. Overexpression of DcR1 has been observed in various cancers and may contribute to tumor resistance to TRAIL-based therapies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Overexpression of DcR1 sequesters TRAIL, preventing apoptosis via DR4/DR5 | PMID: 10679323, PMID: 11526437 |
| Colorectal Cancer | DcR1 upregulation correlates with TRAIL resistance | PMID: 11526437 |
| Non-Small Cell Lung Cancer | DcR1 expression associated with poor prognosis | PMID: 17699744 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 0.0 | Not detected |
| Whole Blood | 0.0 | Not detected |
| Lung | 0.0 | Not detected |
| Colon | 0.0 | Not detected |
| Breast | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.0 | Not detected |
| K-562 | 0.0 | Not detected |
| MCF7 | 0.0 | Not detected |
| A549 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.2T>C | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• TRAIL Signaling Pathway (Reactome: R-HSA-75158)
• Apoptosis (KEGG: hsa04210)
• TNF Signaling (KEGG: hsa04668)
Protein Summary
TNFRSF10C (DcR1) is a 259-amino acid GPI-anchored cell surface protein. It contains two extracellular cysteine-rich domains (CRDs) that bind TRAIL with high affinity but lacks an intracellular death domain. DcR1 functions as a decoy receptor, competing with DR4 and DR5 for TRAIL binding and thereby inhibiting apoptosis. It is expressed in many tissues but at very low levels; overexpression in tumors contributes to TRAIL resistance. The protein is encoded by the TNFRSF10C gene located on chromosome 8p21.3.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TNFRSF10C Knockout HEK293 Cell Line | EDJ-KQ6367 | Human | 8794 | Details Get a Quote |
| TNFRSF10C Knockout HCT 116 Cell Line | EDJ-KQ29026 | Human | 8794 | Details Get a Quote |
| TNFRSF10C Knockout A-549 Cell Line | EDJ-KQ30340 | Human | 8794 | Details Get a Quote |
| TNFRSF10C Knockout HeLa Cell Line | EDJ-KQ55007 | Human | 8794 | Details Get a Quote |
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