TNFAIP8
TNF Alpha Induced Protein 8
Gene Information Card
| Symbol | TNFAIP8 |
|---|---|
| Full Name | TNF Alpha Induced Protein 8 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q23.1 |
| NCBI Gene ID | 25816 ncbi.nlm.nih.gov/gene/25816 |
| Ensembl ID | ENSG00000145777 |
| UniProt ID | O95859 |
| OMIM ID | 612116 |
| HGNC ID | 11918 |
| Aliases | GG2-1, MDC-3.13, SCC-S2, NDED |
Description
TNFAIP8 (TNF Alpha Induced Protein 8) is a protein-coding gene that encodes a negative regulator of apoptosis and NF-kB signaling. The protein is induced by TNF-alpha and plays roles in immune response, inflammation, and cancer progression. Overexpression is observed in various malignancies and is associated with poor prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | Overexpression promotes cell survival and resistance to apoptosis via NF-kB activation | COSMIC, ClinVar |
| Inflammatory diseases | Modulation of NF-kB and apoptosis pathways | NCBI Gene, UniProt |
| Autoimmune disorders | Dysregulation of immune response | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Lung | 8.2 | Medium |
| Breast | 6.1 | Low |
| Colon | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.3 | Cervical cancer cell line |
| A549 | 12.1 | Lung cancer cell line |
| MCF7 | 9.8 | Breast cancer cell line |
| HCT116 | 7.4 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional impact |
| c.100C>T | missense | <0.1% | Reported in COSMIC |
| c.200_201insA | frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations may lead to truncated protein and loss of anti-apoptotic function.
Gain of Function (GOF)
Missense mutations in regulatory regions may increase protein stability or expression.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • negative regulation of apoptotic process | • NF-kappaB signaling |
| • cytoplasm | • nucleus |
| • protein binding |
Pathways
• TNF signaling pathway
• NF-kappa B signaling pathway
• Apoptosis
Protein Summary
The TNFAIP8 protein is a 198-amino acid cytoplasmic and nuclear protein that inhibits caspase-8 activation and modulates NF-kB activity. It is involved in cell survival, proliferation, and immune regulation. Overexpression in tumors correlates with chemoresistance and metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TNFAIP8 Knockout HEK293 Cell Line | EDJ-KQ8243 | Human | 25816 | Details Get a Quote |
| TNFAIP8L1 Knockout HEK293 Cell Line | EDJ-KQ8885 | Human | 126282 | Details Get a Quote |
| TNFAIP8L3 Knockout HEK293 Cell Line | EDJ-KQ15871 | Human | 388121 | Details Get a Quote |
| TNFAIP8 Knockout HCT 116 Cell Line | EDJ-KQ34167 | Human | 25816 | Details Get a Quote |
| TNFAIP8 Knockout HeLa Cell Line | EDJ-KQ34168 | Human | 25816 | Details Get a Quote |
| TNFAIP8L1 Knockout A-549 Cell Line | EDJ-KQ35208 | Human | 126282 | Details Get a Quote |
| TNFAIP8L1 Knockout HCT 116 Cell Line | EDJ-KQ35209 | Human | 126282 | Details Get a Quote |
| TNFAIP8L1 Knockout HeLa Cell Line | EDJ-KQ35210 | Human | 126282 | Details Get a Quote |
| TNFAIP8L3 Knockout A-549 Cell Line | EDJ-KQ49088 | Human | 388121 | Details Get a Quote |
| TNFAIP8L3 Knockout HCT 116 Cell Line | EDJ-KQ49089 | Human | 388121 | Details Get a Quote |
| TNFAIP8L3 Knockout HeLa Cell Line | EDJ-KQ49090 | Human | 388121 | Details Get a Quote |
| TNFAIP8 Knockout A-549 Cell Line | EDJ-KQ32850 | Human | 25816 | Details Get a Quote |
| TNFAIP8L2 Knockout HEK293 Cell Line | EDJ-KQ51685 | Human | 79626 | Details Get a Quote |
| TNFAIP8L2-SCNM1 Knockout HEK293 Cell Line | EDJ-KQ52510 | Human | 100534012 | Details Get a Quote |
| TNFAIP8L2 Knockout HeLa Cell Line | EDJ-KQ57195 | Human | 79626 | Details Get a Quote |
Displaying Records 1 To 15 Of 20 Records
