TNFAIP6
TNF Alpha Induced Protein 6
Gene Information Card
| Symbol | TNFAIP6 |
|---|---|
| Full Name | TNF Alpha Induced Protein 6 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q23.3 |
| NCBI Gene ID | 7130 ncbi.nlm.nih.gov/gene/7130 |
| Ensembl ID | ENSG00000123610 |
| UniProt ID | P98066 |
| OMIM ID | 600630 |
| HGNC ID | 11913 |
| Aliases | TSG-6, TSG6 |
Description
TNFAIP6 (TNF Alpha Induced Protein 6), also known as TSG-6, encodes a secreted hyaluronan-binding protein involved in extracellular matrix stability and inflammation. It is induced by TNF and IL-1 and plays a role in ovulation, arthritis, and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Osteoarthritis | TNFAIP6 modulates hyaluronan crosslinking and inflammation in joint cartilage | PMID: 10880458 |
| Rheumatoid Arthritis | Elevated TNFAIP6 expression in synovium contributes to matrix remodeling | PMID: 11440960 |
| Ovarian Cancer | TNFAIP6 overexpression associated with tumor progression and metastasis | COSMIC: TNFAIP6 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Ovary | 8.3 | Medium |
| Spleen | 6.1 | Low |
| Testis | 4.7 | Low |
| Kidney | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 | 15.2 | Lung carcinoma |
| HeLa | 9.8 | Cervical adenocarcinoma |
| MCF7 | 7.4 | Breast carcinoma |
| HepG2 | 5.1 | Hepatocellular carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown functional impact |
| c.214C>T | missense | <0.01% | Reported in ClinVar as benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • hyaluronic acid binding | • extracellular matrix organization |
| • inflammatory response | • cell adhesion |
Pathways
• TNF signaling pathway
• IL-1 signaling pathway
• Hyaluronan metabolism
Protein Summary
TNFAIP6 encodes a 35 kDa secreted protein (TSG-6) containing a Link domain that binds hyaluronan. It forms complexes with inter-alpha-inhibitor (IαI) to stabilize extracellular matrix and modulate inflammation. Expressed in response to pro-inflammatory cytokines.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TNFAIP6 Knockout HEK293 Cell Line | EDJ-KQ5948 | Human | 7130 | Details Get a Quote |
| TNFAIP6 Knockout A-549 Cell Line | EDJ-KQ28226 | Human | 7130 | Details Get a Quote |
| TNFAIP6 Knockout HeLa Cell Line | EDJ-KQ29503 | Human | 7130 | Details Get a Quote |
| TNFAIP6 Knockout HCT 116 Cell Line | EDJ-KQ71633 | Human | 7130 | Details Get a Quote |
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