TNC (Tenascin C) Gene
Extracellular Matrix Glycoprotein Involved in Tissue Remodeling and Cancer Progression
Gene Information Card
| Symbol | TNC |
|---|---|
| Full Name | Tenascin C |
| Gene Type | protein-coding |
| Chromosomal Location | 9q33.1 |
| NCBI Gene ID | 3371 ncbi.nlm.nih.gov/gene/3371 |
| Ensembl ID | ENSG00000041982 |
| UniProt ID | P24821 |
| OMIM ID | 187380 |
| HGNC ID | 11865 |
| Aliases | TN, HXB, GMEM, GP, 150-225, tenascin |
Description
The TNC gene encodes tenascin C, a large extracellular matrix glycoprotein expressed during embryonic development and in response to tissue injury, inflammation, and neoplasia. It modulates cell adhesion, migration, and signaling, playing critical roles in wound healing, fibrosis, and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioma | TNC overexpression promotes tumor cell invasion and angiogenesis via integrin and EGFR signaling | PMID: 23563181 |
| Breast Cancer | Elevated TNC in stroma correlates with poor prognosis and metastasis through activation of Wnt and Notch pathways | PMID: 21502524 |
| Rheumatoid Arthritis | TNC expression in synovium contributes to joint inflammation and cartilage degradation | PMID: 20037588 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 0.8 | Low |
| Heart | 1.2 | Low |
| Lung | 3.5 | Medium |
| Liver | 0.5 | Low |
| Kidney | 1.0 | Low |
| Breast | 2.1 | Medium |
| Ovary | 4.8 | Medium |
| Testis | 0.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| U-251 MG (glioma) | 12.5 | High expression |
| MCF7 (breast cancer) | 3.2 | Moderate expression |
| A549 (lung cancer) | 1.8 | Low expression |
| HepG2 (liver cancer) | 0.6 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | missense | <0.1% | Unknown functional impact |
| c.4567_4569del | in-frame deletion | <0.1% | Altered fibronectin type III domain |
| c.7890G>A | nonsense | <0.1% | Premature truncation, likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Rare nonsense and frameshift variants predicted to cause haploinsufficiency; not commonly observed in germline disease.
Gain of Function (GOF)
Overexpression and gene amplification in cancers (e.g., glioma, breast) lead to enhanced cell migration and invasion.
Dominant Negative (DN)
Not well documented for TNC; most pathogenic effects are due to overexpression rather than dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
| • extracellular matrix structural constituent | • cell adhesion |
| • cell migration | • angiogenesis |
| • wound healing | • integrin binding |
Pathways
• ECM-receptor interaction (KEGG hsa04512)
• Focal adhesion (KEGG hsa04510)
• PI3K-Akt signaling pathway (KEGG hsa04151)
• TGF-beta signaling pathway
Protein Summary
Tenascin C is a hexameric extracellular matrix glycoprotein composed of multiple fibronectin type III repeats and a fibrinogen-like domain. It is highly expressed during development and in pathological conditions such as cancer, where it promotes tumor cell proliferation, migration, and angiogenesis. Its expression is regulated by growth factors and mechanical stress, and it interacts with integrins, EGFR, and Toll-like receptors to modulate cellular responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TNC Knockout HEK293 Cell Line | EDJ-KQ876 | Human | 3371 | Details Get a Quote |
| TNC Knockout HeLa Cell Line | EDJ-KQ19689 | Human | 3371 | Details Get a Quote |
| TNC Knockout A-549 Cell Line | EDJ-KQ62065 | Human | 3371 | Details Get a Quote |
| TNC Knockout HCT 116 Cell Line | EDJ-KQ70548 | Human | 3371 | Details Get a Quote |
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