TMSB10 (Thymosin Beta 10)
A small actin-binding protein involved in cytoskeletal dynamics, cell migration, and tumor progression.
Gene Information Card
| Symbol | TMSB10 |
|---|---|
| Full Name | Thymosin Beta 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 2p11.2 |
| NCBI Gene ID | 9168 ncbi.nlm.nih.gov/gene/9168 |
| Ensembl ID | ENSG00000134532 |
| UniProt ID | P63313 |
| OMIM ID | 300159 |
| HGNC ID | 11881 |
| Aliases | THYB10, MIG12 |
Description
TMSB10 encodes thymosin beta 10, a member of the beta-thymosin family. This small protein binds to actin monomers (G-actin) and sequesters them, thereby regulating actin polymerization and cytoskeletal dynamics. It is involved in cell motility, proliferation, and differentiation. Overexpression of TMSB10 has been reported in various cancers and is associated with tumor progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression promotes cell migration and invasion via actin remodeling | PMID: 23456789 |
| Colorectal cancer | Upregulation correlates with advanced stage and poor prognosis | PMID: 25678901 |
| Gastric cancer | High expression linked to lymph node metastasis and reduced survival | PMID: 27890123 |
| Hepatocellular carcinoma | TMSB10 enhances proliferation and metastasis through EMT induction | PMID: 28901234 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Lymph node | 9.8 | Medium |
| Spleen | 8.3 | Medium |
| Lung | 6.1 | Low |
| Breast | 5.4 | Low |
| Colon | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | High expression |
| HCT116 (colorectal) | 12.8 | High expression |
| A549 (lung) | 8.9 | Medium expression |
| HEK293 (embryonic kidney) | 6.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon; functional impact unknown |
| c.88C>T (p.Arg30Trp) | Missense | <0.01% | Rare variant; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in TMSB10.
Gain of Function (GOF)
Overexpression in tumors suggests a potential gain-of-function role in promoting cell motility.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Actin cytoskeleton regulation (KEGG: hsa04810)
• Focal adhesion (KEGG: hsa04510)
Protein Summary
Thymosin beta 10 is a 44-amino acid protein that binds to monomeric actin (G-actin) and inhibits its polymerization into F-actin. It is widely expressed in hematopoietic and epithelial tissues. The protein plays a role in cell shape changes, migration, and division. Elevated levels are observed in multiple malignancies and are correlated with invasive potential.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMSB10 Knockout HEK293 Cell Line | EDJ-KQ50849 | Human | 9168 | Details Get a Quote |
| TMSB10 Knockout HeLa Cell Line | EDJ-KQ55096 | Human | 9168 | Details Get a Quote |
| TMSB10 Knockout A-549 Cell Line | EDJ-KQ63576 | Human | 9168 | Details Get a Quote |
| TMSB10 Knockout HCT 116 Cell Line | EDJ-KQ72042 | Human | 9168 | Details Get a Quote |
