TMEM177: Transmembrane Protein 177
A mitochondrial inner membrane protein with potential roles in cellular respiration and cancer
Gene Information Card
| Symbol | TMEM177 |
|---|---|
| Full Name | Transmembrane Protein 177 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q11.2 |
| NCBI Gene ID | 80775 ncbi.nlm.nih.gov/gene/80775 |
| Ensembl ID | ENSG00000162946 |
| UniProt ID | Q9BUN1 |
| OMIM ID | 617850 |
| HGNC ID | 28264 |
| Aliases | MGC13017, FLJ22693 |
Description
TMEM177 (Transmembrane Protein 177) is a protein-coding gene located on chromosome 2q11.2. The encoded protein is a mitochondrial inner membrane protein that may be involved in mitochondrial function and cellular respiration. Expression data suggest broad tissue distribution with highest levels in heart and skeletal muscle. Mutations and altered expression have been reported in various cancers, though functional characterization remains limited.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression; potential role in mitochondrial dysfunction | COSMIC; TCGA |
| Colorectal cancer | Somatic mutations observed; possible tumor suppressor role | COSMIC |
| Lung cancer | Copy number alterations and expression changes | COSMIC; TCGA |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Skeletal muscle | 10.8 | Medium |
| Liver | 6.2 | Low |
| Brain | 4.1 | Low |
| Kidney | 5.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.7 | Embryonic kidney cells |
| HeLa | 6.4 | Cervical cancer cells |
| MCF7 | 7.1 | Breast cancer cells |
| A549 | 5.9 | Lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287G>A (p.Arg96His) | Missense | 0.02% | Unknown; predicted benign |
| c.412C>T (p.Pro138Ser) | Missense | 0.01% | Unknown; predicted possibly damaging |
| c.523_524insA | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.523_524insA) likely result in truncated protein and loss of mitochondrial localization.
Gain of Function (GOF)
No evidence for gain-of-function mutations in TMEM177.
Dominant Negative (DN)
No evidence for dominant-negative mutations in TMEM177.
View complete mutation data：
Gene Ontology (GO)
| • mitochondrial inner membrane (GO:0005743) | • integral component of membrane (GO:0016021) |
| • mitochondrion (GO:0005739) |
Pathways
• No curated pathways available
Protein Summary
TMEM177 is a 177-amino acid transmembrane protein localized to the mitochondrial inner membrane. It contains a single transmembrane domain and is predicted to function in mitochondrial organization or respiration. The protein is ubiquitously expressed with highest levels in metabolically active tissues. Structural studies are lacking, and its molecular function remains to be fully elucidated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM177 Knockout HEK293 Cell Line | EDJ-KQ9575 | Human | 80775 | Details Get a Quote |
| TMEM177 Knockout A-549 Cell Line | EDJ-KQ36390 | Human | 80775 | Details Get a Quote |
| TMEM177 Knockout HCT 116 Cell Line | EDJ-KQ36391 | Human | 80775 | Details Get a Quote |
| TMEM177 Knockout HeLa Cell Line | EDJ-KQ36392 | Human | 80775 | Details Get a Quote |
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