TMEM176B
Transmembrane Protein 176B: A Potential Immune Modulator and Tumor Suppressor
Gene Information Card
| Symbol | TMEM176B |
|---|---|
| Full Name | Transmembrane Protein 176B |
| Gene Type | Protein coding |
| Chromosomal Location | 7q36.1 |
| NCBI Gene ID | 28959 ncbi.nlm.nih.gov/gene/28959 |
| Ensembl ID | ENSG00000106565 |
| UniProt ID | Q5BJH7 |
| OMIM ID | 610279 |
| HGNC ID | 28770 |
| Aliases | FLJ20481, MGC117188, MGC117189, MGC117190 |
Description
TMEM176B encodes a transmembrane protein that belongs to the TMEM176 family. It is involved in immune regulation, particularly in dendritic cell maturation and T-cell activation. The protein is also implicated in tumor suppression, with reduced expression observed in various cancers. TMEM176B is located on chromosome 7q36.1 and is expressed in multiple tissues, with highest levels in immune-related organs.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Reduced expression of TMEM176B may promote tumor growth through immune evasion. | PMID: 25605247 |
| Breast Cancer | Downregulation associated with poor prognosis and altered immune response. | PMID: 29187725 |
| Lung Cancer | Loss of TMEM176B expression linked to increased metastasis. | PMID: 30093546 |
| Autoimmune Diseases | Potential role in modulating T-cell responses, though specific mechanisms are unclear. | PMID: 23543789 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph Node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone Marrow | 8.9 | Medium |
| Lung | 6.3 | Low |
| Colon | 4.1 | Low |
| Breast | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | High expression in kidney-derived cells |
| HeLa | 8.5 | Moderate expression in cervical cancer cells |
| A549 | 4.2 | Low expression in lung cancer cells |
| MCF7 | 3.1 | Low expression in breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200C>T (p.Pro67Leu) | Missense | <0.1% | Unknown functional impact |
| c.340G>A (p.Gly114Arg) | Missense | <0.1% | Potential loss of function |
| c.500_501insA | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of function, potentially reducing immune regulation.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative mutations have been described.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
| • immune response (GO:0006955) | • innate immune response (GO:0045087) |
| • signal transduction (GO:0007165) |
Pathways
• Immune System (Reactome: R-HSA-168256)
• Innate Immune System (Reactome: R-HSA-168249)
Protein Summary
TMEM176B is a 176-amino acid transmembrane protein with four predicted transmembrane domains. It is localized to the plasma membrane and endoplasmic reticulum. The protein is involved in immune modulation, particularly in dendritic cell function and T-cell activation. Its exact molecular function remains under investigation, but it is thought to regulate calcium signaling and immune synapse formation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM176B Knockout HEK293 Cell Line | EDJ-KQ2352 | Human | 28959 | Details Get a Quote |
| TMEM176B Knockout HeLa Cell Line | EDJ-KQ22780 | Human | 28959 | Details Get a Quote |
| TMEM176B Knockout A-549 Cell Line | EDJ-KQ64562 | Human | 28959 | Details Get a Quote |
| TMEM176B Knockout HCT 116 Cell Line | EDJ-KQ73019 | Human | 28959 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
