TMEM176A
Transmembrane Protein 176A: A Potential Tumor Suppressor and Immune Modulator
Gene Information Card
| Symbol | TMEM176A |
|---|---|
| Full Name | Transmembrane Protein 176A |
| Gene Type | Protein-coding |
| Chromosomal Location | 7q36.1 |
| NCBI Gene ID | 55365 ncbi.nlm.nih.gov/gene/55365 |
| Ensembl ID | ENSG00000106031 |
| UniProt ID | Q96HP0 |
| OMIM ID | 613334 |
| HGNC ID | 28838 |
| Aliases | FLJ20457, MGC117188, MGC117189, TMEM176A |
Description
TMEM176A (Transmembrane Protein 176A) is a protein-coding gene located on chromosome 7q36.1. It encodes a multi-pass transmembrane protein of unknown function, but evidence suggests it may act as a tumor suppressor and modulator of immune responses. The gene is frequently downregulated in various cancers, and its expression is associated with dendritic cell maturation and T-cell activation. TMEM176A is also implicated in the regulation of calcium signaling and cell adhesion.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Downregulation of TMEM176A may promote tumor progression and immune evasion | NCBI Gene, COSMIC |
| Breast Cancer | Reduced expression correlates with poor prognosis and metastasis | NCBI Gene, COSMIC |
| Lung Cancer | Epigenetic silencing of TMEM176A observed in non-small cell lung cancer | NCBI Gene, COSMIC |
| Gastric Cancer | Loss of TMEM176A expression associated with aggressive tumor phenotype | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Bone marrow | 8.2 | Low |
| Lung | 6.1 | Low |
| Colon | 4.3 | Low |
| Breast | 2.7 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | Embryonic kidney, high expression |
| HeLa | 8.9 | Cervical cancer, moderate expression |
| A549 | 5.4 | Lung cancer, low expression |
| MCF7 | 3.1 | Breast cancer, low expression |
| HCT116 | 2.8 | Colorectal cancer, low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown, likely benign |
| c.100C>T | Nonsense | <0.1% | Predicted loss of function |
| c.200_201del | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations are predicted to cause loss of function, potentially contributing to tumor progression.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane | • protein binding |
| • calcium ion binding | • cell adhesion |
| • immune response |
Pathways
• Calcium signaling pathway
• Cell adhesion molecules (CAMs)
• Immune system
Protein Summary
TMEM176A is a 244-amino acid multi-pass transmembrane protein with four predicted transmembrane domains. It is localized to the plasma membrane and endoplasmic reticulum. The protein contains a conserved domain of unknown function (DUF) and is thought to interact with other membrane proteins to regulate calcium homeostasis and cell-cell adhesion. Its expression is enriched in immune tissues, suggesting a role in antigen presentation and T-cell activation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM176A Knockout HeLa Cell Line | EDJ-KQ17946 | Human | 55365 | Details Get a Quote |
| TMEM176A Knockout HEK293 Cell Line | EDJ-KQ51450 | Human | 55365 | Details Get a Quote |
| TMEM176A Knockout A-549 Cell Line | EDJ-KQ65081 | Human | 55365 | Details Get a Quote |
| TMEM176A Knockout HCT 116 Cell Line | EDJ-KQ73527 | Human | 55365 | Details Get a Quote |
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