TMEM145: Transmembrane Protein 145
A poorly characterized transmembrane protein with potential roles in cellular signaling and disease.
Gene Information Card
| Symbol | TMEM145 |
|---|---|
| Full Name | Transmembrane Protein 145 |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.42 |
| NCBI Gene ID | 284507 ncbi.nlm.nih.gov/gene/284507 |
| Ensembl ID | ENSG00000188290 |
| UniProt ID | Q8N9V2 |
| OMIM ID | 617750 |
| HGNC ID | 28313 |
| Aliases | FLJ32709, MGC16384 |
Description
TMEM145 (Transmembrane Protein 145) is a protein-coding gene located on chromosome 19q13.42. The encoded protein is predicted to contain transmembrane domains, suggesting a role in membrane-associated processes. Currently, its specific biological function is not fully characterized, but it may be involved in cell signaling or transport. Expression data indicate broad but low-level expression across various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 0.8 | Low |
| Heart | 0.5 | Low |
| Liver | 0.3 | Low |
| Kidney | 0.6 | Low |
| Testis | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.9 | Low expression |
| HeLa | 0.7 | Low expression |
| K562 | 0.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane (GO:0016021) |
Protein Summary
TMEM145 is a transmembrane protein of unknown function. It is predicted to localize to cellular membranes and may participate in intercellular communication or transport. No functional studies have been published to date.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM145 Knockout HEK293 Cell Line | EDJ-KQ15796 | Human | 284339 | Details Get a Quote |
| TMEM145 Knockout A-549 Cell Line | EDJ-KQ48994 | Human | 284339 | Details Get a Quote |
| TMEM145 Knockout HCT 116 Cell Line | EDJ-KQ48995 | Human | 284339 | Details Get a Quote |
| TMEM145 Knockout HeLa Cell Line | EDJ-KQ59451 | Human | 284339 | Details Get a Quote |
