TMEM140: Transmembrane Protein 140
A poorly characterized transmembrane protein with potential roles in cancer and cellular signaling.
Gene Information Card
| Symbol | TMEM140 |
|---|---|
| Full Name | Transmembrane Protein 140 |
| Gene Type | Protein coding |
| Chromosomal Location | 7q22.1 |
| NCBI Gene ID | 55281 ncbi.nlm.nih.gov/gene/55281 |
| Ensembl ID | ENSG00000106333 |
| UniProt ID | Q9H0A9 |
| OMIM ID | 618444 |
| HGNC ID | 26238 |
| Aliases | FLJ10305, MGC13170 |
Description
TMEM140 (Transmembrane Protein 140) is a protein-coding gene located on chromosome 7q22.1. It encodes a multi-pass membrane protein of unknown function. Expression data suggest roles in various tissues, and alterations have been reported in cancer, though detailed functional studies are limited.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Potential role in tumorigenesis; altered expression observed | NCBI Gene, COSMIC |
| Not specified | Insufficient evidence for specific disease association | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 2.3 | Low |
| Lung | 1.8 | Low |
| Liver | 1.5 | Low |
| Kidney | 2.1 | Low |
| Testis | 3.0 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 2.5 | Cervical cancer cell line |
| A549 | 1.9 | Lung cancer cell line |
| HEK293 | 2.0 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown |
| c.100C>T | Missense | <0.1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane | • membrane |
Protein Summary
TMEM140 is a 140-amino acid transmembrane protein with multiple membrane-spanning domains. Its exact function is unknown, but it is predicted to be involved in cellular signaling or transport. No crystal structure is available.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM140 Knockout HEK293 Cell Line | EDJ-KQ51442 | Human | 55281 | Details Get a Quote |
| TMEM140 Knockout HeLa Cell Line | EDJ-KQ56569 | Human | 55281 | Details Get a Quote |
| TMEM140 Knockout A-549 Cell Line | EDJ-KQ65066 | Human | 55281 | Details Get a Quote |
| TMEM140 Knockout HCT 116 Cell Line | EDJ-KQ73511 | Human | 55281 | Details Get a Quote |
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