TLCD5 Gene - TLC Domain Containing 5
A comprehensive resource on TLCD5, including genomic information, expression, and disease associations.
Gene Information Card
| Symbol | TLCD5 |
|---|---|
| Full Name | TLC domain containing 5 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q13.1 |
| NCBI Gene ID | 100506334 ncbi.nlm.nih.gov/gene/100506334 |
| Ensembl ID | ENSG00000204176 |
| UniProt ID | Q5T2W1 |
| OMIM ID | Not available |
| HGNC ID | HGNC:37298 |
| Aliases | C11orf63, FLJ45831 |
Description
TLCD5 (TLC domain containing 5) is a protein-coding gene located on chromosome 11q13.1. The gene encodes a protein of unknown function that contains a TLC (TRAM/LAG1/CLN8) domain, which is often associated with lipid metabolism and membrane trafficking. Expression data suggest broad but low-level transcription across many tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations | Not established | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.3 | Low |
| Thyroid | 1.8 | Low |
| Adrenal gland | 1.5 | Low |
| Brain | 1.2 | Low |
| Lung | 1.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.8 | Low expression |
| K562 | 0.5 | Low expression |
| HeLa | 0.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Gene Ontology (GO)
| • molecular_function (GO:0003674) | • cellular_component (GO:0005575) |
| • biological_process (GO:0008150) |
Protein Summary
The TLCD5 protein (UniProt Q5T2W1) is 224 amino acids long and contains a TLC domain. Its exact function is unknown, but the TLC domain is implicated in lipid sensing and transport. No structural or functional studies are currently available.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TLCD5 Knockout HEK293 Cell Line | EDJ-KQ8427 | Human | 219902 | Details Get a Quote |
| TLCD5 Knockout HeLa Cell Line | EDJ-KQ33195 | Human | 219902 | Details Get a Quote |
| TLCD5 Knockout A-549 Cell Line | EDJ-KQ34529 | Human | 219902 | Details Get a Quote |
| TLCD5 Knockout HCT 116 Cell Line | EDJ-KQ34530 | Human | 219902 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
