THRAP3
Thyroid Hormone Receptor Associated Protein 3
Gene Information Card
| Symbol | THRAP3 |
|---|---|
| Full Name | thyroid hormone receptor associated protein 3 |
| Gene Type | protein coding |
| Chromosomal Location | 1p34.3 |
| NCBI Gene ID | 9967 ncbi.nlm.nih.gov/gene/9967 |
| Ensembl ID | ENSG00000117650 |
| UniProt ID | Q9Y2W1 |
| OMIM ID | 603809 |
| HGNC ID | 11788 |
| Aliases | TRAP150, BCLAF1-interacting protein, THRAP3 |
Description
THRAP3 (thyroid hormone receptor associated protein 3) encodes a component of the thyroid hormone receptor-associated complex (TRAP/Mediator complex) involved in transcriptional regulation. The protein also functions in pre-mRNA splicing, DNA damage response, and cell cycle control. THRAP3 is ubiquitously expressed and has been implicated in various cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression and altered splicing of THRAP3 may promote tumorigenesis | PMID: 23455423 |
| Colorectal cancer | THRAP3 mutations and dysregulation associated with poor prognosis | PMID: 27149991 |
| Hepatocellular carcinoma | THRAP3 upregulation linked to cell proliferation and migration | PMID: 29367642 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 28.5 | High |
| Lymph node | 22.3 | High |
| Brain | 15.7 | Medium |
| Liver | 12.1 | Medium |
| Heart | 9.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.2 | Cervical cancer cell line |
| HEK293 | 15.6 | Embryonic kidney cells |
| MCF7 | 21.4 | Breast cancer cell line |
| HepG2 | 14.3 | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | missense | 0.02% | p.Pro412Ser; uncertain significance |
| c.567_568del | frameshift | 0.01% | p.Glu189Aspfs*5; loss of function |
| c.890A>G | synonymous | 0.05% | p.Thr297Thr; no effect |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to premature stop codons are predicted to cause loss of function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • transcription coactivator activity | • RNA binding |
| • protein binding | • nucleus |
| • mRNA splicing | • via spliceosome |
| • DNA repair |
Pathways
• Mediator complex
• mRNA splicing
• DNA damage response
Protein Summary
THRAP3 is a 955-amino acid protein that localizes to the nucleus and participates in the Mediator complex, bridging transcription factors with RNA polymerase II. It also interacts with splicing factors and is involved in alternative splicing regulation. Post-translational modifications include phosphorylation, which modulates its function in DNA repair and cell cycle progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| THRAP3 Knockout HEK293 Cell Line | EDJ-KQ6843 | Human | 9967 | Details Get a Quote |
| THRAP3 Knockout HCT 116 Cell Line | EDJ-KQ30032 | Human | 9967 | Details Get a Quote |
| THRAP3 Knockout A-549 Cell Line | EDJ-KQ31394 | Human | 9967 | Details Get a Quote |
| THRAP3 Knockout HeLa Cell Line | EDJ-KQ31395 | Human | 9967 | Details Get a Quote |
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