THEM4 Gene (Thioesterase Superfamily Member 4)
Acyl-CoA thioesterase involved in fatty acid metabolism and potential tumor suppression
Gene Information Card
| Symbol | THEM4 |
|---|---|
| Full Name | Thioesterase Superfamily Member 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q25.3 |
| NCBI Gene ID | 117145 ncbi.nlm.nih.gov/gene/117145 |
| Ensembl ID | ENSG00000162614 |
| UniProt ID | Q5T1C6 |
| OMIM ID | 615856 |
| HGNC ID | 28467 |
| Aliases | ACOT4, MGC13170 |
Description
THEM4 (thioesterase superfamily member 4) encodes an acyl-CoA thioesterase that catalyzes the hydrolysis of acyl-CoAs to free fatty acids and coenzyme A. The enzyme is involved in lipid metabolism and may play a role in cellular energy homeostasis. THEM4 has been implicated in tumor suppression through modulation of fatty acid oxidation and apoptosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered expression may affect fatty acid metabolism and cell survival | COSMIC mutation data; literature reports |
| Colorectal cancer | Downregulation observed; potential tumor suppressor role | PubMed studies; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Heart | 6.1 | Low |
| Brain | 2.4 | Low |
| Testis | 15.7 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.2 | Liver cancer cell line |
| HEK293 | 7.8 | Embryonic kidney cells |
| MCF7 | 4.5 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown significance |
| c.100C>T | Nonsense | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., c.100C>T) are predicted to cause premature truncation and loss of enzyme activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • acyl-CoA hydrolase activity | • fatty acid metabolic process |
| • cytoplasm | • mitochondrion |
Pathways
• Fatty acid metabolism
• Peroxisome proliferator-activated receptor (PPAR) signaling pathway
Protein Summary
THEM4 is a 35 kDa acyl-CoA thioesterase localized to the cytoplasm and mitochondria. It hydrolyzes medium- to long-chain acyl-CoAs, regulating intracellular fatty acid levels and CoA availability. The protein may influence lipid signaling and energy metabolism, with potential roles in cancer biology.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| THEM4 Knockout HEK293 Cell Line | EDJ-KQ875 | Human | 117145 | Details Get a Quote |
| THEM4 Knockout A-549 Cell Line | EDJ-KQ19686 | Human | 117145 | Details Get a Quote |
| THEM4 Knockout HCT 116 Cell Line | EDJ-KQ19687 | Human | 117145 | Details Get a Quote |
| THEM4 Knockout HeLa Cell Line | EDJ-KQ19688 | Human | 117145 | Details Get a Quote |
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