TFPI2
Tissue Factor Pathway Inhibitor 2
Gene Information Card
| Symbol | TFPI2 |
|---|---|
| Full Name | Tissue Factor Pathway Inhibitor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q21.3 |
| NCBI Gene ID | 7980 ncbi.nlm.nih.gov/gene/7980 |
| Ensembl ID | ENSG00000105825 |
| UniProt ID | P48307 |
| OMIM ID | 600033 |
| HGNC ID | 11760 |
| Aliases | PP5, TFPI-2, REF1 |
Description
TFPI2 (Tissue Factor Pathway Inhibitor 2) encodes a serine protease inhibitor belonging to the Kunitz-type inhibitor family. The protein inhibits a broad range of serine proteases including plasmin, trypsin, chymotrypsin, and factor VIIa/tissue factor complex. It is highly expressed in the placenta and is involved in extracellular matrix remodeling, coagulation regulation, and tumor suppression. Epigenetic silencing via promoter methylation is frequently observed in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Placental dysfunction | Altered TFPI2 expression may affect trophoblast invasion and coagulation balance at the maternal-fetal interface. | PMID: 12368206 |
| Colorectal cancer | Promoter hypermethylation of TFPI2 leads to transcriptional silencing and loss of tumor suppressor function. | PMID: 17638982 |
| Gastric cancer | Reduced TFPI2 expression due to methylation correlates with tumor progression and poor prognosis. | PMID: 20097252 |
| Pancreatic cancer | TFPI2 methylation is a frequent epigenetic event associated with invasive phenotype. | PMID: 15696243 |
| Hepatocellular carcinoma | TFPI2 downregulation via methylation promotes metastasis and angiogenesis. | PMID: 20629109 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | 1234.5 | High |
| Liver | 12.3 | Low |
| Lung | 8.7 | Low |
| Kidney | 6.2 | Low |
| Heart | 3.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 45.2 | Cervical cancer cell line |
| MCF7 | 22.8 | Breast cancer cell line |
| HepG2 | 15.6 | Hepatocellular carcinoma cell line |
| A549 | 9.4 | Lung adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional impact |
| c.200C>T | nonsense | <0.1% | Predicted loss of function |
| c.350G>A | missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., c.200C>T) are predicted to cause premature truncation and loss of protein function.
Gain of Function (GOF)
No gain-of-function mutations reported in TFPI2.
Dominant Negative (DN)
No dominant-negative mutations reported in TFPI2.
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase inhibitor activity | • extracellular matrix binding |
| • negative regulation of coagulation | • negative regulation of angiogenesis |
| • extracellular space |
Pathways
• Tissue factor (TF) pathway
• Plasminogen activating cascade
• Extracellular matrix organization
Protein Summary
TFPI2 is a 213-amino-acid secreted protein containing three Kunitz domains. It inhibits serine proteases such as plasmin, trypsin, and the factor VIIa-tissue factor complex. The protein is heavily glycosylated and localizes to the extracellular matrix. It plays a key role in regulating pericellular proteolysis, coagulation, and tumor invasion. Loss of TFPI2 expression via promoter methylation is a common event in multiple cancers, contributing to metastatic progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TFPI2 Knockout HEK293 Cell Line | EDJ-KQ6152 | Human | 7980 | Details Get a Quote |
| TFPI2 Knockout HeLa Cell Line | EDJ-KQ29958 | Human | 7980 | Details Get a Quote |
| TFPI2 Knockout A-549 Cell Line | EDJ-KQ28646 | Human | 7980 | Details Get a Quote |
| TFPI2 Knockout HCT 116 Cell Line | EDJ-KQ71769 | Human | 7980 | Details Get a Quote |
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