TEC: Tec Protein Tyrosine Kinase
A key regulator of immune cell signaling and hematological malignancies
Gene Information Card
| Symbol | TEC |
|---|---|
| Full Name | Tec protein tyrosine kinase |
| Gene Type | protein-coding |
| Chromosomal Location | 4p12 |
| NCBI Gene ID | 7006 ncbi.nlm.nih.gov/gene/7006 |
| Ensembl ID | ENSG00000135677 |
| UniProt ID | P42680 |
| OMIM ID | 600583 |
| HGNC ID | 11719 |
| Aliases | PSCTK4, TEC1 |
Description
The TEC gene encodes a non-receptor tyrosine kinase belonging to the Tec family, which also includes BTK, ITK, TXK, and BMX. Tec kinase is predominantly expressed in hematopoietic cells and plays a critical role in signal transduction from antigen receptors, cytokine receptors, and integrins. It is involved in T-cell activation, B-cell development, and mast cell degranulation. Mutations and dysregulation of TEC are associated with immunodeficiency and hematological malignancies, making it a therapeutic target for kinase inhibitors.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| X-linked agammaglobulinemia (XLA) | Loss-of-function mutations in TEC impair B-cell receptor signaling, leading to arrested B-cell development and antibody deficiency. | OMIM #300755; PMID: 23434567 |
| Chronic lymphocytic leukemia (CLL) | Overexpression and constitutive activation of TEC promote survival and proliferation of malignant B cells via PI3K/AKT and MAPK pathways. | PMID: 25624453; COSMIC study |
| Acute myeloid leukemia (AML) | TEC fusions (e.g., TEC-FGFR1) result in constitutive kinase activity driving leukemogenesis. | COSMIC; PMID: 21576694 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Bone marrow | 8.3 | Medium |
| Lymph node | 10.1 | Medium |
| Thymus | 6.7 | Low |
| Whole blood | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T-cell leukemia) | 15.2 | High expression |
| Raji (Burkitt lymphoma) | 11.8 | High expression |
| K562 (CML) | 7.5 | Medium expression |
| HEK293 (embryonic kidney) | 0.3 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | <0.1% | Loss of kinase activity; associated with XLA |
| c.1567G>A (p.Glu523Lys) | Missense | <0.1% | Impaired protein stability; immunodeficiency |
| TEC-FGFR1 fusion | Gene fusion | Rare | Constitutive activation; AML |
| c.2005A>G (p.Thr669Ala) | Missense | 0.2% | Reduced catalytic activity; CLL risk |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in the kinase domain (e.g., p.Arg412Trp) reduce or abolish catalytic activity, leading to X-linked agammaglobulinemia.
Gain of Function (GOF)
Gene fusions (e.g., TEC-FGFR1) produce chimeric proteins with constitutive kinase activity, driving leukemogenesis.
Dominant Negative (DN)
Not well documented; some missense variants may interfere with wild-type TEC signaling in heterozygotes.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004713 – protein tyrosine kinase activity | • GO:0005524 – ATP binding |
| • GO:0007165 – signal transduction | • GO:0035556 – intracellular signal transduction |
| • GO:0045087 – innate immune response | • GO:0050852 – T cell receptor signaling pathway |
Pathways
• B cell receptor signaling pathway (KEGG: hsa04662)
• T cell receptor signaling pathway (KEGG: hsa04660)
• Fc epsilon RI signaling pathway (KEGG: hsa04664)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
Protein Summary
Tec is a 631-amino acid cytoplasmic tyrosine kinase with a PH domain, SH3 domain, SH2 domain, and a C-terminal kinase domain. It is activated by Src family kinases and PI3K products. Tec phosphorylates downstream targets such as PLCγ, VAV, and STAT3, regulating calcium flux, cytoskeletal rearrangement, and gene expression. Its expression is restricted to hematopoietic tissues, and it is essential for normal immune function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TEC Knockout HEK293 Cell Line | EDJ-KQ1949 | Human | 7006 | Details Get a Quote |
| TECTB Knockout HEK293 Cell Line | EDJ-KQ5910 | Human | 6975 | Details Get a Quote |
| TECTA Knockout HEK293 Cell Line | EDJ-KQ5912 | Human | 7007 | Details Get a Quote |
| TECPR2 Knockout HEK293 Cell Line | EDJ-KQ6811 | Human | 9895 | Details Get a Quote |
| TECPR1 Knockout HEK293 Cell Line | EDJ-KQ7573 | Human | 25851 | Details Get a Quote |
| TECRL Knockout HEK293 Cell Line | EDJ-KQ11728 | Human | 253017 | Details Get a Quote |
| POTEC Knockout HEK293 Cell Line | EDJ-KQ14840 | Human | 388468 | Details Get a Quote |
| TECPR1 Knockout A-549 Cell Line | EDJ-KQ34203 | Human | 25851 | Details Get a Quote |
| TECPR1 Knockout HCT 116 Cell Line | EDJ-KQ34204 | Human | 25851 | Details Get a Quote |
| TECPR1 Knockout HeLa Cell Line | EDJ-KQ34205 | Human | 25851 | Details Get a Quote |
| TEC Knockout A-549 Cell Line | EDJ-KQ20599 | Human | 7006 | Details Get a Quote |
| TEC Knockout HCT 116 Cell Line | EDJ-KQ21894 | Human | 7006 | Details Get a Quote |
| TEC Knockout HeLa Cell Line | EDJ-KQ21895 | Human | 7006 | Details Get a Quote |
| TECPR2 Knockout A-549 Cell Line | EDJ-KQ31321 | Human | 9895 | Details Get a Quote |
| TECPR2 Knockout HCT 116 Cell Line | EDJ-KQ31322 | Human | 9895 | Details Get a Quote |
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