TDRD15
Tudor Domain Containing 15
Gene Information Card
| Symbol | TDRD15 |
|---|---|
| Full Name | Tudor domain containing 15 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q31.1 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000204103 |
| UniProt ID | Q8N9W6 |
| OMIM ID | 617246 |
| HGNC ID | HGNC:37236 |
| Aliases | FLJ45831, TDRD15 |
Description
TDRD15 (Tudor domain containing 15) is a protein-coding gene located on chromosome 2q31.1. It encodes a protein containing a Tudor domain, which is involved in RNA binding and may play a role in germ cell development and chromatin regulation. Expression is enriched in testis and certain cancer cell lines.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Thyroid | 2.1 | Low |
| Prostate | 1.8 | Low |
| Lung | 1.2 | Low |
| Breast | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 5.4 | Moderate expression |
| HeLa | 3.2 | Low expression |
| K562 | 1.1 | Low expression |
| A549 | 0.8 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • Tudor domain |
| • nucleus | • cytoplasm |
Protein Summary
The TDRD15 protein contains a Tudor domain, a conserved motif that mediates protein-protein and protein-RNA interactions. It is predicted to localize to the nucleus and cytoplasm and may be involved in RNA metabolism and germ cell development. No functional studies have been published.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TDRD15 Knockout HEK293 Cell Line | EDJ-KQ15674 | Human | 100129278 | Details Get a Quote |
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