TDRD10
Tudor Domain Containing 10
Gene Information Card
| Symbol | TDRD10 |
|---|---|
| Full Name | Tudor Domain Containing 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q32.33 |
| NCBI Gene ID | 126668 ncbi.nlm.nih.gov/gene/126668 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q6P9H4 |
| OMIM ID | 617538 |
| HGNC ID | 28720 |
| Aliases | FLJ32709, TDRD10A |
Description
TDRD10 (Tudor Domain Containing 10) is a protein-coding gene located on chromosome 14q32.33. It encodes a protein containing a Tudor domain, which is often involved in binding methylated arginine or lysine residues on other proteins, playing roles in RNA processing, chromatin regulation, and germ cell development. The gene is expressed in various tissues, with notable levels in testis and certain cancer cell lines.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Thyroid | 6.2 | Low |
| Prostate | 5.1 | Low |
| Lung | 4.8 | Low |
| Breast | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.3 | Embryonic kidney |
| HeLa | 6.7 | Cervical carcinoma |
| K562 | 5.2 | Leukemia |
| HepG2 | 4.1 | Hepatocellular carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic mutations | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Gene Ontology (GO)
| • Tudor domain binding | • RNA binding |
| • nucleus | • cytoplasm |
Pathways
• No specific pathway assigned
Protein Summary
The TDRD10 protein (UniProt Q6P9H4) contains a Tudor domain, a conserved motif that recognizes methylated arginine or lysine residues. This domain is implicated in protein-protein interactions, particularly in the context of RNA metabolism and chromatin dynamics. The precise biological function of TDRD10 remains under investigation, but its expression pattern suggests roles in spermatogenesis and cellular signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TDRD10 Knockout HEK293 Cell Line | EDJ-KQ8937 | Human | 126668 | Details Get a Quote |
| TDRD10 Knockout HeLa Cell Line | EDJ-KQ58183 | Human | 126668 | Details Get a Quote |
| TDRD10 Knockout A-549 Cell Line | EDJ-KQ66673 | Human | 126668 | Details Get a Quote |
| TDRD10 Knockout HCT 116 Cell Line | EDJ-KQ75088 | Human | 126668 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
