TAF7: TATA-Box Binding Protein Associated Factor 7
A key component of the TFIID complex involved in transcription initiation and cell cycle regulation.
Gene Information Card
| Symbol | TAF7 |
|---|---|
| Full Name | TATA-box binding protein associated factor 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q31.1 |
| NCBI Gene ID | 6879 ncbi.nlm.nih.gov/gene/6879 |
| Ensembl ID | ENSG00000113522 |
| UniProt ID | Q15545 |
| OMIM ID | 600573 |
| HGNC ID | 11544 |
| Aliases | TAF2F, TAFII55, TAFII-55, TAF(II)55 |
Description
TAF7 (TATA-box binding protein associated factor 7) encodes a component of the transcription factor IID (TFIID) complex. This protein is essential for transcription initiation by RNA polymerase II, interacting with TBP and other TAFs to facilitate promoter recognition and pre-initiation complex assembly. TAF7 also plays roles in cell cycle progression and DNA repair.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | TAF7 overexpression may promote cell proliferation via enhanced transcription of cell cycle genes. | COSMIC; PMID: 23535729 |
| Breast cancer | Altered TAF7 expression correlates with poor prognosis; potential role in transcriptional dysregulation. | COSMIC; PMID: 25691885 |
| Lung cancer | TAF7 mutations and copy number alterations observed in non-small cell lung cancer. | COSMIC; PMID: 22955915 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 25.4 | High |
| Lymph node | 18.2 | High |
| Bone marrow | 15.7 | High |
| Brain | 8.3 | Medium |
| Liver | 6.1 | Medium |
| Heart | 4.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 22.1 | Cervical carcinoma; high expression |
| K562 | 19.8 | Leukemia; moderate expression |
| A549 | 14.5 | Lung carcinoma; moderate expression |
| MCF7 | 12.3 | Breast cancer; moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | <0.01% | Unknown; reported in COSMIC |
| c.521G>A (p.Arg174His) | Missense | <0.01% | Unknown; reported in COSMIC |
| c.688_689insA (p.Thr230Asnfs*2) | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Thr230Asnfs*2) likely result in truncated protein and loss of TFIID complex interaction.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported.
Dominant Negative (DN)
Missense mutations in conserved domains may disrupt TFIID assembly, potentially acting in a dominant-negative manner.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Transcription initiation by RNA polymerase II (Reactome: R-HSA-75953)
• TFIID complex assembly (Reactome: R-HSA-109581)
Protein Summary
TAF7 is a 55 kDa protein that contains a histone fold domain and a TBP-binding region. It is a stable component of the TFIID complex, where it helps recruit RNA polymerase II to core promoters. TAF7 also interacts with transcription factors such as Sp1 and p53, modulating their activity. Post-translational modifications include phosphorylation, which may regulate its function during the cell cycle.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAF7L Knockout HEK293 Cell Line | EDJ-KQ11424 | Human | 54457 | Details Get a Quote |
| TAF7L Knockout HCT 116 Cell Line | EDJ-KQ39671 | Human | 54457 | Details Get a Quote |
| TAF7 Knockout HEK293 Cell Line | EDJ-KQ50671 | Human | 6879 | Details Get a Quote |
| TAF7 Knockout HeLa Cell Line | EDJ-KQ54609 | Human | 6879 | Details Get a Quote |
| TAF7L Knockout HeLa Cell Line | EDJ-KQ56418 | Human | 54457 | Details Get a Quote |
| TAF7 Knockout A-549 Cell Line | EDJ-KQ63090 | Human | 6879 | Details Get a Quote |
| TAF7L Knockout A-549 Cell Line | EDJ-KQ64911 | Human | 54457 | Details Get a Quote |
| TAF7 Knockout HCT 116 Cell Line | EDJ-KQ71562 | Human | 6879 | Details Get a Quote |
