TACC2: Transforming Acidic Coiled-Coil Containing Protein 2
A centrosomal and microtubule-associated protein implicated in cell cycle regulation and cancer
Gene Information Card
| Symbol | TACC2 |
|---|---|
| Full Name | transforming acidic coiled-coil containing protein 2 |
| Gene Type | protein coding |
| Chromosomal Location | 10q26.13 |
| NCBI Gene ID | 10579 ncbi.nlm.nih.gov/gene/10579 |
| Ensembl ID | ENSG00000138162 |
| UniProt ID | Q9Y6A5 |
| OMIM ID | 605302 |
| HGNC ID | 11523 |
| Aliases | AZU-1, ECTACC, TACC2a, TACC2b, TACC2c |
Description
TACC2 (transforming acidic coiled-coil containing protein 2) encodes a member of the transforming acidic coiled-coil (TACC) family. The protein localizes to centrosomes and microtubules during interphase and to the mitotic spindle during mitosis. It plays a role in centrosome integrity, microtubule stabilization, and cell cycle progression. TACC2 is involved in transcriptional regulation and has been implicated in tumor suppression and oncogenesis depending on cellular context.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered TACC2 expression affects centrosome function and genomic stability; loss of expression correlates with tumor progression | PMID: 15064718, COSMIC |
| Glioma | TACC2 amplification or overexpression contributes to mitotic spindle defects and aneuploidy | PMID: 24803665, COSMIC |
| Lung cancer | Downregulation of TACC2 is associated with poor prognosis and increased metastasis | PMID: 21804532 |
| Prostate cancer | TACC2 acts as a putative tumor suppressor; reduced expression linked to aggressive disease | PMID: 15604208 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Breast | 8.3 | Low |
| Lung | 6.7 | Low |
| Testis | 25.1 | High |
| Heart | 4.2 | Low |
| Liver | 3.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | Embryonic kidney; moderate expression |
| HeLa | 9.8 | Cervical carcinoma; low expression |
| MCF7 | 7.1 | Breast cancer; low expression |
| U87MG | 22.4 | Glioblastoma; high expression |
| A549 | 5.3 | Lung carcinoma; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | 0.02% (gnomAD) | Loss of function; premature truncation |
| c.567_568insA (p.Glu190fs) | Frameshift | 0.01% (COSMIC) | Loss of function; protein truncation |
| c.2101G>A (p.Glu701Lys) | Missense | 0.05% (gnomAD) | Unknown; predicted benign by SIFT |
| c.89C>T (p.Pro30Leu) | Missense | 0.03% (gnomAD) | Unknown; predicted tolerated |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations (e.g., p.Arg412*, p.Glu190fs) lead to truncated protein lacking C-terminal TACC domain, impairing centrosomal localization and microtubule binding.
Gain of Function (GOF)
Not clearly established; amplification of TACC2 in some cancers may lead to overexpression and aberrant mitotic spindle function.
Dominant Negative (DN)
Not reported for TACC2.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Centrosome maturation and spindle assembly
• Microtubule cytoskeleton organization
• Cell cycle
• mitotic
Protein Summary
TACC2 is a 639-amino-acid protein (isoform 1) containing an N-terminal acidic region and a C-terminal coiled-coil TACC domain. It localizes to centrosomes and microtubules, interacting with ch-TOG (CKAP5) and clathrin to stabilize microtubules during mitosis. TACC2 is involved in centrosome integrity, spindle assembly, and cell cycle progression. Alternative splicing generates multiple isoforms with distinct expression patterns and functions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TACC2 Knockout HEK293 Cell Line | EDJ-KQ3143 | Human | 10579 | Details Get a Quote |
| TACC2 Knockout A-549 Cell Line | EDJ-KQ23145 | Human | 10579 | Details Get a Quote |
| TACC2 Knockout HCT 116 Cell Line | EDJ-KQ24531 | Human | 10579 | Details Get a Quote |
| TACC2 Knockout HeLa Cell Line | EDJ-KQ24532 | Human | 10579 | Details Get a Quote |
