TACC1: Transforming Acidic Coiled-Coil Containing Protein 1
A centrosomal and microtubule-associated protein implicated in cell cycle regulation and cancer
Gene Information Card
| Symbol | TACC1 |
|---|---|
| Full Name | Transforming acidic coiled-coil containing protein 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 8p11.22 |
| NCBI Gene ID | 6867 ncbi.nlm.nih.gov/gene/6867 |
| Ensembl ID | ENSG00000104419 |
| UniProt ID | Q9Y6A5 |
| OMIM ID | 605301 |
| HGNC ID | 11522 |
| Aliases | KIAA1108, TACC1A, TACC1B |
Description
TACC1 (Transforming acidic coiled-coil containing protein 1) encodes a member of the transforming acidic coiled-coil (TACC) family. The protein localizes to centrosomes and microtubules during mitosis, playing a role in spindle stabilization and cell cycle progression. TACC1 is involved in transcriptional regulation and has been implicated in various cancers, including breast, ovarian, and lung cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | TACC1 overexpression promotes centrosome amplification and aneuploidy | PMID: 15077110 |
| Ovarian cancer | TACC1 amplification at 8p11.22 contributes to tumorigenesis | PMID: 17699752 |
| Lung cancer | TACC1 expression correlates with poor prognosis and metastasis | PMID: 21444677 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 14.2 | Medium |
| Bone marrow | 8.5 | Low |
| Brain | 6.1 | Low |
| Breast | 5.3 | Low |
| Ovary | 4.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 12.3 | High expression |
| A549 (lung cancer) | 9.8 | Moderate expression |
| HeLa (cervical cancer) | 7.4 | Low expression |
| HEK293 (embryonic kidney) | 6.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1042C>T (p.Arg348Trp) | Missense | <0.1% | Unknown functional impact |
| c.1573G>A (p.Glu525Lys) | Missense | <0.1% | Unknown functional impact |
| Amplification | Copy number gain | ~5% in breast cancer | Potential oncogenic activation |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
Gene amplification and overexpression are associated with oncogenic activity in breast and ovarian cancers.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • centrosome (GO:0005813) | • microtubule (GO:0005874) |
| • protein binding (GO:0005515) | • cell division (GO:0051301) |
| • cell population proliferation (GO:0008283) |
Pathways
• Centrosome maturation and spindle assembly
• Cell cycle
• mitotic
• TACC family signaling
Protein Summary
TACC1 is a 805-amino acid protein containing a conserved coiled-coil domain at the C-terminus. It localizes to centrosomes and the mitotic spindle, where it interacts with ch-TOG (CKAP5) to stabilize microtubule attachments. TACC1 also shuttles to the nucleus and may regulate transcription. Overexpression leads to centrosome amplification and chromosomal instability.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TACC1 Knockout HEK293 Cell Line | EDJ-KQ2858 | Human | 6867 | Details Get a Quote |
| TACC1 Knockout HCT 116 Cell Line | EDJ-KQ22510 | Human | 6867 | Details Get a Quote |
| TACC1 Knockout A-549 Cell Line | EDJ-KQ23877 | Human | 6867 | Details Get a Quote |
| TACC1 Knockout HeLa Cell Line | EDJ-KQ23879 | Human | 6867 | Details Get a Quote |
