SVIP (Small VCP/p97-Interacting Protein)
A regulator of VCP/p97 ATPase activity involved in protein degradation and cellular stress responses.
Gene Information Card
| Symbol | SVIP |
|---|---|
| Full Name | Small VCP/p97-Interacting Protein |
| Gene Type | Protein coding |
| Chromosomal Location | 11p13 |
| NCBI Gene ID | 258010 ncbi.nlm.nih.gov/gene/258010 |
| Ensembl ID | ENSG00000149273 |
| UniProt ID | Q8NHG7 |
| OMIM ID | 614509 |
| HGNC ID | 28463 |
| Aliases | DKFZp686A01247, FLJ38973 |
Description
SVIP encodes a small protein that interacts with valosin-containing protein (VCP/p97), a key ATPase involved in ubiquitin-dependent protein degradation, endoplasmic reticulum-associated degradation (ERAD), and autophagy. SVIP inhibits VCP ATPase activity and modulates cellular stress responses, including proteotoxic stress and autophagy regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | SVIP dysregulation may alter VCP-mediated protein degradation, affecting tumor growth and stress adaptation. | COSMIC; limited direct evidence |
| Neurodegenerative disorders | Impaired VCP regulation by SVIP could contribute to protein aggregation and ER stress. | Inferred from VCP function; not directly validated in ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Heart | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Moderate expression |
| HeLa | 7.8 | Low expression |
| K562 | 6.5 | Low expression |
| MCF7 | 5.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Potential loss of start codon; effect unknown |
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Predicted loss-of-function mutations may reduce SVIP-mediated inhibition of VCP, leading to dysregulated protein degradation.
Gain of Function (GOF)
No known gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • identical protein binding (GO:0042802) |
| • ATPase inhibitor activity (GO:0051117) | • ubiquitin-dependent protein catabolic process (GO:0006511) |
| • ER-associated ubiquitin-dependent protein catabolic process (GO:0030433) |
Pathways
• VCP/p97-mediated degradation (Reactome: R-HSA-983168)
• ERAD pathway (Reactome: R-HSA-8951664)
Protein Summary
SVIP is a 76-amino acid protein that directly binds to the N-terminal domain of VCP/p97, inhibiting its ATPase activity. This interaction regulates VCP's role in ERAD, autophagy, and proteostasis. SVIP is localized to the cytoplasm and nucleus, and its expression is induced under stress conditions. The protein is conserved in vertebrates and plays a critical role in maintaining cellular homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SVIP Knockout HEK293 Cell Line | EDJ-KQ12003 | Human | 258010 | Details Get a Quote |
| SVIP Knockout A-549 Cell Line | EDJ-KQ40586 | Human | 258010 | Details Get a Quote |
| SVIP Knockout HCT 116 Cell Line | EDJ-KQ40587 | Human | 258010 | Details Get a Quote |
| SVIP Knockout HeLa Cell Line | EDJ-KQ40588 | Human | 258010 | Details Get a Quote |
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