SULT1C2: Sulfotransferase Family 1C Member 2
Cytosolic sulfotransferase involved in xenobiotic metabolism and hormone sulfation.
Gene Information Card
| Symbol | SULT1C2 |
|---|---|
| Full Name | Sulfotransferase Family 1C Member 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q12.3 |
| NCBI Gene ID | 6819 ncbi.nlm.nih.gov/gene/6819 |
| Ensembl ID | ENSG00000115970 |
| UniProt ID | O00338 |
| OMIM ID | 602386 |
| HGNC ID | 11455 |
| Aliases | ST1C2, SULT1C1, SULT1C2A |
Description
SULT1C2 encodes a member of the sulfotransferase family that catalyzes the sulfate conjugation of various xenobiotics, hormones, and neurotransmitters. This cytosolic enzyme uses 3'-phosphoadenosine-5'-phosphosulfate (PAPS) as a sulfate donor. SULT1C2 is involved in the metabolism of drugs, thyroid hormones, and phenolic compounds, and is expressed in multiple tissues including liver, kidney, and gastrointestinal tract.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Altered sulfation of xenobiotics may affect detoxification and carcinogen activation; SULT1C2 expression changes observed in tumor tissues. | NCBI Gene, PubMed |
| Thyroid hormone metabolism disorders | SULT1C2 sulfates thyroid hormones, potentially modulating their activity and clearance. | UniProt, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Small intestine | 6.1 | Low |
| Colon | 4.7 | Low |
| Stomach | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Hepatocellular carcinoma cell line |
| Caco-2 | 7.5 | Colorectal adenocarcinoma cell line |
| HEK293 | 2.1 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.94G>A (p.Gly32Arg) | Missense | <0.01% | Unknown functional effect; rare population variant |
| c.523C>T (p.Arg175Trp) | Missense | <0.01% | Potential loss of sulfotransferase activity |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may reduce enzyme activity, but no confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No gain-of-function mutations documented.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Sulfation of thyroid hormones (Reactome: R-HSA-209776)
• Xenobiotic metabolism (KEGG: hsa00980)
Protein Summary
SULT1C2 is a 305-amino acid cytosolic sulfotransferase that catalyzes the transfer of a sulfate group from PAPS to a variety of substrates, including small phenols, thyroid hormones, and drugs. The protein is expressed in liver, kidney, and gastrointestinal tissues, and plays a role in detoxification and hormone regulation. Structural studies indicate a conserved PAPS-binding domain and substrate-binding pocket.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SULT1C2 Knockout HEK293 Cell Line | EDJ-KQ14783 | Human | 6819 | Details Get a Quote |
| SULT1C2 Knockout HCT 116 Cell Line | EDJ-KQ46421 | Human | 6819 | Details Get a Quote |
| SULT1C2 Knockout HeLa Cell Line | EDJ-KQ54588 | Human | 6819 | Details Get a Quote |
| SULT1C2 Knockout A-549 Cell Line | EDJ-KQ63072 | Human | 6819 | Details Get a Quote |
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