SULT1A3: Sulfotransferase Family 1A Member 3
Cytosolic sulfotransferase involved in dopamine and catecholamine metabolism
Gene Information Card
| Symbol | SULT1A3 |
|---|---|
| Full Name | Sulfotransferase Family 1A Member 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 16p11.2 |
| NCBI Gene ID | 6818 ncbi.nlm.nih.gov/gene/6818 |
| Ensembl ID | ENSG00000161921 |
| UniProt ID | P50224 |
| OMIM ID | 600642 |
| HGNC ID | 11454 |
| Aliases | ST1A3, ST1A5, HAST3, M-PST, TL-PST |
Description
SULT1A3 encodes a cytosolic sulfotransferase that catalyzes the sulfate conjugation of catecholamines, including dopamine, norepinephrine, and epinephrine, as well as phenolic monoamines. This enzyme plays a key role in the inactivation and metabolism of neurotransmitters and drugs. The gene is located on chromosome 16p11.2 and is highly expressed in the brain, liver, and gastrointestinal tract.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Parkinson disease | Altered dopamine sulfation may affect neurotransmitter homeostasis | PMID: 12815056 |
| Neuroblastoma | SULT1A3 expression correlates with catecholamine metabolism in tumors | PMID: 10441467 |
| Sulfotransferase deficiency | Loss-of-function variants impair catecholamine sulfation | ClinVar: RCV000015777 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 25.6 | Medium |
| Liver | 18.3 | Medium |
| Small intestine | 12.1 | Low |
| Kidney | 8.4 | Low |
| Adrenal gland | 6.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 32.5 | Neuroblastoma cell line |
| HepG2 | 15.8 | Hepatocellular carcinoma |
| Caco-2 | 10.2 | Colorectal adenocarcinoma |
| HEK293 | 5.1 | Embryonic kidney |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.638G>A (p.Arg213His) | Missense | 0.001 | Reduced enzyme activity |
| c.1A>G (p.Met1Val) | Start loss | <0.001 | Loss of function |
| c.107C>T (p.Pro36Leu) | Missense | 0.002 | Decreased sulfation capacity |
Mutation functional classification
Loss of Function (LOF)
c.1A>G (p.Met1Val) leads to complete loss of protein expression.
Gain of Function (GOF)
No gain-of-function variants reported.
Dominant Negative (DN)
No dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Sulfation of catecholamines (Reactome: R-HSA-174362)
• Phase II conjugation (Reactome: R-HSA-156580)
Protein Summary
SULT1A3 is a 295-amino acid cytosolic sulfotransferase that transfers a sulfo group from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to the hydroxyl group of catecholamines and phenolic monoamines. It is a homodimer with a molecular weight of approximately 34 kDa. The enzyme is critical for the inactivation of dopamine and other neurotransmitters, and its activity is regulated by substrate availability and post-translational modifications.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SULT1A3 Knockout HEK293 Cell Line | EDJ-KQ50667 | Human | 6818 | Details Get a Quote |
| SULT1A3 Knockout HeLa Cell Line | EDJ-KQ54587 | Human | 6818 | Details Get a Quote |
| SULT1A3 Knockout A-549 Cell Line | EDJ-KQ63071 | Human | 6818 | Details Get a Quote |
| SULT1A3 Knockout HCT 116 Cell Line | EDJ-KQ71547 | Human | 6818 | Details Get a Quote |
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